{
  "abstract": "Background\n\nBreast implants are widely used in plastic surgery and generally considered safe. However, recent reports of implant-associated malignancies, including anaplastic large-cell lymphoma and squamous-cell carcinoma, have raised concern. This report presents a case of squamous-cell carcinoma arising in a silicone breast implant and reviews the current literature on its association with breast implants.Case presentation\n\nA 48-year-old Hispanic female presented with pain and asymmetry of the left breast. Persistent symptoms and imaging findings led to the identification of a cystic mass associated with a silicone implant. Histopathological analysis confirmed squamous-cell carcinoma arising from the periprosthetic capsule. The patient underwent implant removal, and after radiologic surveillance and diagnosis of recurrence, an attempted oncoplastic approach was converted intraoperatively to a radical mastectomy due to extensive tumor infiltration. No adjuvant therapy was administered. At 12-month follow-up, the patient remains disease-free without evidence of recurrence.Conclusions\n\nThe diagnosis and management of breast-implant-associated squamous-cell carcinoma require a multidisciplinary approach due to its unpredictable behavior. Increased awareness, early detection, and individualized treatment strategies are essential to improve outcomes in this rare but aggressive entity.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medicine, Universidad de los Andes, Bogotá, Colombia. g.villegasg@uniandes.edu.co.",
    "School of Medicine, Universidad de los Andes, Bogotá, Colombia.",
    "Department of Pathology and Laboratory Medicine, Fundación Santa Fe de Bogotá, Bogotá, Colombia.",
    "Department of Surgery, Fundación Santa Fe de Bogotá, Bogotá, Colombia. maria.rizo@fsfb.org.co."
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gustavo Adolfo Villegas-Gomez",
      "orcid": "0000-0002-7193-2994"
    },
    {
      "affs": [
        1
      ],
      "name": "Valentina Pérez-Ariza"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Marcela Mejía-Arango"
    },
    {
      "affs": [
        3
      ],
      "name": "María Isabel Rizo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7z605wj6w98vd.bib",
  "cited_by": 0,
  "doi": "10.1186/s13256-026-05867-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13685378",
  "id": "7z605wj6w98vd",
  "issns": [
    "1752-1947"
  ],
  "landing_url": "https://europepmc.org/article/MED/42902393",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2746|Breast Implant and Reconstruction"
    ]
  ],
  "openalex": "W7170284901",
  "pdf_url": "https://europepmc.org/articles/PMC13685378?pdf=render",
  "pmcid": "PMC13685378",
  "pmid": "42902393",
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7z605wj6w98vd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42902393",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42902393"
    },
    {
      "first_seen": "2026-10-30T13:45:59Z",
      "native_id": "e553c5dbd7eb425d8d80b83a6c75497f",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s13256-026-05867-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Breast Implant and Reconstruction",
      "subfield": "surgery"
    }
  ],
  "title": "S. carcinoma arising in a breast implant: a case report and review of the literature.",
  "title_text": "S. carcinoma arising in a breast implant: a case report and review of the literature.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:59Z",
  "url": "https://research.draconitic.com/paper/7z605wj6w98vd",
  "venue": "Journal of medical case reports",
  "versions": []
}