{
  "abstract": "Pain is a prevalent and disabling symptom of myotonic dystrophy type 1 (DM1), yet its underlying mechanisms remain poorly understood. Using HSA LR20b transgenic mice, we found multimodal mechanical and thermal hypersensitivity. Whole-cell electrophysiological recordings demonstrated depolarized resting membrane potentials and increased action potential firing selectively in small- and medium-diameter dorsal root ganglion neurons. These findings identify peripheral nociceptor sensitization as a potential mechanism contributing to pain in DM1.",
  "abstract_shown": true,
  "affiliations": [
    "University of Florida College of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "T. S. Nelson"
    },
    {
      "name": "A. Calderon-Rivera"
    },
    {
      "name": "S. Hestehava"
    },
    {
      "name": "S. Loya-Lopez"
    },
    {
      "name": "K. Gomez"
    },
    {
      "name": "P. Duran"
    },
    {
      "affs": [
        0
      ],
      "name": "R. Khanna"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7zfcy87fr1s76.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.10.750655",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750655v1.full",
  "id": "7zfcy87fr1s76",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750655v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2737|Pain Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7213434533",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750655v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7zfcy87fr1s76.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:41Z",
      "native_id": "10.64898/2026.09.10.750655",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750655v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability",
  "title_text": "A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:41Z",
  "url": "https://research.draconitic.com/paper/7zfcy87fr1s76",
  "venue": "bioRxiv",
  "versions": []
}