{
  "abstract": "Thiazoles are privileged N-heterocyclic scaffolds ubiquitous in FDA-approved drugs, yet their clinical utility can be compromised by oxidative metabolism at the heterobenzylic position. Inspired by the metabolic-blocking strategy used in dabrafenib development, herein we report an iron-catalyzed strategy for direct α-quaternization of (benzo)­thiazoles using unactivated alkenes. Under the proposed pathway, alkene-derived carbon-centered radicals undergo regioselective C2 addition and oxidative rearomatization, providing α-quaternary products without heteroarene preactivation or stoichiometric Lewis acids, thereby enabling analogue diversification.",
  "abstract_shown": true,
  "affiliations": [
    "Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea",
    "College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 34134, Republic of Korea",
    "Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinwoo Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Chaeryn Jeong"
    },
    {
      "affs": [
        0
      ],
      "name": "Hyungwoo Choi"
    },
    {
      "affs": [
        0
      ],
      "name": "Seok Beom Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Joonseok Jang"
    },
    {
      "affs": [
        0
      ],
      "name": "Sangmyung Han"
    },
    {
      "affs": [
        1
      ],
      "name": "Yohan Park",
      "orcid": "0000-0001-6844-2241"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Suckchang Hong",
      "orcid": "0000-0003-4975-9192"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7zq0sdragntxn.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c04036",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13711634/",
  "id": "7zq0sdragntxn",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://doi.org/10.1021/acs.orglett.6c04036",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Letter"
    ],
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7221042011",
  "pdf_url": "https://pubs.acs.org/orlef7/article-pdf/doi/10.1021/acs.orglett.6c04036/68780386/acs.orglett.6c04036.pdf",
  "pmcid": "PMC13711634",
  "pmid": "42925180",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7zq0sdragntxn.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:22Z",
      "native_id": "PMC13711634",
      "source": "pmc",
      "url": "https://doi.org/10.1021/acs.orglett.6c04036"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Carbon Quaternization at the α‑Position of Thiazoles: Iron-Catalyzed Hydroheteroarylation Using Unactivated Alkenes",
  "title_text": "Carbon Quaternization at the α‑Position of Thiazoles: Iron-Catalyzed Hydroheteroarylation Using Unactivated Alkenes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:22Z",
  "url": "https://research.draconitic.com/paper/7zq0sdragntxn",
  "venue": "Organic Letters",
  "versions": []
}