{
  "abstract": "Arginine methylation regulates diverse cellular processes, yet how methyl-arginine reader proteins couple this modification to kinase signaling in vivo remains poorly defined. Here, we identify staphylococcal nuclease and Tudor domain containing 1 (SND1) as a pancreas-enriched effector that links symmetric dimethylarginine (SDMA) recognition to S6 kinase 2 (S6K2) activation. Disruption of SDMA-mediated binding by a point mutation in the SND1 Tudor domain markedly diminishes ribosomal protein S6 (S6) phosphorylation in the pancreas. Mechanistically, SND1 engages SDMA-modified arginines within the carboxyl-terminal glycine-arginine-rich (GAR) motif of S6K2 and promotes S6K2-dependent S6 phosphorylation. Mice harboring lysine substitutions at these GAR arginines (S6k2 RK) phenocopy Snd1 Tudor-mutant (Snd1 knock-in) animals, exhibiting impaired pancreatic S6 phosphorylation. Transcriptomic analyses reveal extensive overlap in dysregulated pathways between Snd1 and S6k2 mutant pancreata, supporting a shared signaling cascade. Together, these findings establish a methylation-dependent reader-kinase axis that links protein arginine methyltransferase 5-catalyzed arginine methylation to tissue-specific control of ribosome signaling and cellular stress adaptation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
    "Center for Immunotherapy and Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yalong Wang",
      "orcid": "0000-0002-9557-9101"
    },
    {
      "affs": [
        0
      ],
      "name": "Bin Liu",
      "orcid": "0000-0002-9113-9694"
    },
    {
      "affs": [
        0
      ],
      "name": "Rongjie Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei He"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniel J. McGrail",
      "orcid": "0000-0002-6669-6069"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Xu",
      "orcid": "0000-0002-8654-461X"
    },
    {
      "affs": [
        0
      ],
      "name": "Mark T. Bedford",
      "orcid": "0000-0002-8899-1050"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7zvy6tp04c0fg.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aei1547",
  "fulltext_url": "https://europepmc.org/articles/PMC13693660",
  "id": "7zvy6tp04c0fg",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aei1547",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Cancer-related gene regulation"
    ]
  ],
  "openalex": "W7223318421",
  "pdf_url": "https://europepmc.org/articles/PMC13693660?pdf=render",
  "pmcid": "PMC13693660",
  "pmid": "42913003",
  "published": "2026-10-23",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/7zvy6tp04c0fg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aei1547",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aei1547"
    },
    {
      "first_seen": "2026-10-30T12:20:03Z",
      "native_id": "MED:42913003",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42913003"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Cancer-related gene regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "A methylation-dependent reader couples arginine methylation to S6K2 signaling in vivo",
  "title_text": "A methylation-dependent reader couples arginine methylation to S6K2 signaling in vivo",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:03Z",
  "url": "https://research.draconitic.com/paper/7zvy6tp04c0fg",
  "venue": "Science Advances",
  "versions": []
}