{
  "abstract": "Feline pulmonary Langerhans cell histiocytosis (FPLCH) is a rare histiocytic disorder in cats, usually diagnosed post‐mortem following natural death or euthanasia for severe respiratory distress. Antemortem diagnosis has been reported only once, achieved by cytologic examination of bronchoalveolar lavage fluid combined with immunocytochemistry, whereas fine‐needle aspiration (FNA) of lung nodules was previously reported as non‐diagnostic. Here we describe two cases of FPLCH in which cytology of ultrasound‐guided lung‐nodule FNA yielded diagnostic material, including from one cat with an atypical clinical presentation. Whereas case 1 presented with severe respiratory distress, case 2 had no respiratory signs. Both specimens were highly cellular and composed of atypical cells morphologically most consistent with histiocytes showing moderate atypia. A combination of postmortem gross, histopathologic, immunophenotypic, and ultrastructural findings confirmed the cytologic suspicion of FPLCH. To our knowledge, this is the first cytologic description of FPLCH in FNA samples from lung nodules and the first report of a confirmed case without respiratory signs.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USA",
    "Faculty of Veterinary Medicine–Lusófona University–Lisbon University Center Lisbon Portugal",
    "Department of Small Animal Clinical Sciences, Institute of Veterinary Science University of Liverpool Neston UK",
    "Anicura Restelo Veterinary Hospital Lisbon Portugal",
    "Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, Leahurst Campus University of Liverpool Neston UK",
    "IDEXX Laboratories Barcelona Spain",
    "Vedis – Veterinary Expertise in Diagnosis Porto Portugal"
  ],
  "article_type": "case study",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Karuna Katariwala"
    },
    {
      "affs": [
        1
      ],
      "name": "Martim Matias"
    },
    {
      "affs": [
        2
      ],
      "name": "Isabel Amores‐Fuster"
    },
    {
      "affs": [
        3
      ],
      "name": "Doroteia Bota"
    },
    {
      "affs": [
        4
      ],
      "name": "Guido Rocchigiani"
    },
    {
      "affs": [
        5
      ],
      "name": "Carolina Naranjo",
      "orcid": "0009-0004-0563-7737"
    },
    {
      "affs": [
        6
      ],
      "name": "Nazaré Pinto da Cunha"
    },
    {
      "affs": [
        0
      ],
      "name": "Martina Piviani",
      "orcid": "0000-0002-2399-8649"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7zy13skc90xnr.bib",
  "cited_by": 0,
  "doi": "10.1111/vcp.70141",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13730990/",
  "id": "7zy13skc90xnr",
  "issns": [
    "0275-6382",
    "1939-165X"
  ],
  "landing_url": "https://doi.org/10.1111/vcp.70141",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Special Supplement: Histiocytes in Health and Disease"
    ],
    [
      "openalex",
      "2720|Histiocytic Disorders and Treatments"
    ]
  ],
  "openalex": "W7203497072",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/vcp.70141",
  "pmcid": "PMC13730990",
  "pmid": "42596859",
  "published": "2026-08-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7zy13skc90xnr.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:16Z",
      "native_id": "PMC13730990",
      "source": "pmc",
      "url": "https://doi.org/10.1111/vcp.70141"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Histiocytic Disorders and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Fine‐Needle Aspirate Cytology of Feline Pulmonary Langerhans Cell Histiocytosis in Two Cats",
  "title_text": "Fine‐Needle Aspirate Cytology of Feline Pulmonary Langerhans Cell Histiocytosis in Two Cats",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:16Z",
  "url": "https://research.draconitic.com/paper/7zy13skc90xnr",
  "venue": "Veterinary Clinical Pathology",
  "versions": []
}