{
  "abstract": "Obesity prevalence continues to rise worldwide, with 1/3 of children and 2/3 of adults forecasted to be living with obesity by 2050 (1).Obesity is associated with >20 nonoverlapping diseases across multiple organ systems, and people with obesity have up to 12 times increased risk of developing complex multimorbidity (2).The heritability of obesity is estimated to be 40-70% (3), though the degree to which the epigenome is modifiable through different exposures remains unresolved.The gestational environment represents one's first exposure following genetic recombination, a time of extreme growth and cell differentiation.Maternal obesity produces offspring with a phenotype characterized by obesity, dyslipidemia, hypertension, and metabolic inflexibility (4).However, epigenetic programming resulting from maternal obesity has not been fully explored.The study by Wilson et al, (5) provides insight into the effects of maternal obesity on the epigenetic modifications in the offspring heart.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ, United States",
    "Department of Cellular and Molecular Medicine, Sarver Heart Center, College of Medicine, University of Arizona, Tucson, AZ, United States"
  ],
  "article_type": "article commentary",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dallin Tavoian"
    },
    {
      "affs": [
        1
      ],
      "name": "Sakthivel Sadayappan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8008w1r57s85m.bib",
  "cited_by": 0,
  "doi": "10.1152/ajpheart.90292.2026",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13718736/",
  "id": "8008w1r57s85m",
  "issns": [
    "0363-6135",
    "1522-1539"
  ],
  "landing_url": "https://doi.org/10.1152/ajpheart.90292.2026",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2735|Birth, Development, and Health"
    ]
  ],
  "openalex": "W7223687681",
  "pdf_url": "https://journals.physiology.org/doi/pdf/10.1152/ajpheart.90292.2026?download=true",
  "pmcid": "PMC13718736",
  "pmid": "42932951",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8008w1r57s85m.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:42Z",
      "native_id": "PMC13718736",
      "source": "pmc",
      "url": "https://doi.org/10.1152/ajpheart.90292.2026"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2735|Birth, Development, and Health",
      "subfield": "reproductive-child"
    }
  ],
  "title": "The Kids Aren’t Alright: Maternal Obesity Leaves a Sex-Specific Epigenetic Mark on the Offspring Heart",
  "title_text": "The Kids Aren’t Alright: Maternal Obesity Leaves a Sex-Specific Epigenetic Mark on the Offspring Heart",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:42Z",
  "url": "https://research.draconitic.com/paper/8008w1r57s85m",
  "venue": "American journal of physiology. Heart and circulatory physiology",
  "versions": []
}