{
  "abstract": "Individual variation in human attractiveness to mosquitoes critically influences vector-borne disease transmission, and this phenomenon arises from multiple underlying factors. This study integrated human skin microbiome profiling, non-human primate in situ intervention, and volatilomics to uncover a microbial-mediated mechanism underlying host-specific mosquito repellency. Bacillus species were identified as a microbial signature associated with reduced mosquito attraction in humans. Targeted Intervention of B. licheniformis and B. paralicheniformis on primate skin was sufficient to significantly reduce mosquito attraction, thereby establishing a causal microbial contribution beyond descriptive correlations. Mechanistic analyses revealed that Bacillus enrichment reprogrammed the skin volatilome, specifically increasing the abundance of aromatic and fatty acid-derived effectors, such as p-Cresol and decanoic acid, which are associated with repellency phenotypes. Together, these findings revealed a potential role of skin commensals in shaping mosquito host-seeking behavior, providing a molecular basis for microbiome-informed and bio-inspired strategies for mosquito disease control.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Zhenyu Gu"
    },
    {
      "name": "Heting Gao"
    },
    {
      "name": "Hongxia Guo"
    },
    {
      "name": "Zhihua Fan"
    },
    {
      "name": "Weixian Zhang"
    },
    {
      "name": "Dan Xing"
    },
    {
      "name": "Xinyu Zhou"
    },
    {
      "name": "Haotian Yu",
      "orcid": "0000-0002-4944-5743"
    },
    {
      "name": "Teng Zhao",
      "orcid": "0000-0003-2143-3350"
    },
    {
      "name": "Jiahong Wu",
      "orcid": "0000-0001-6453-1570"
    },
    {
      "name": "Chunxiao Li",
      "orcid": "0000-0001-6017-0915"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/801cyzdq6sza9.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78356-5",
  "fulltext_url": "https://europepmc.org/articles/PMC13680614",
  "id": "801cyzdq6sza9",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78356-5",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1109|Insect symbiosis and bacterial influences"
    ]
  ],
  "openalex": "W7127398242",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78356-5.pdf",
  "pmcid": "PMC13680614",
  "pmid": "42897181",
  "published": "2026-10-19",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/801cyzdq6sza9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-78356-5",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78356-5"
    },
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42897181",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897181"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1109|Insect symbiosis and bacterial influences",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Mosquito repellency mediated by skin commensal Bacillus species via volatile metabolite reprogramming",
  "title_text": "Mosquito repellency mediated by skin commensal Bacillus species via volatile metabolite reprogramming",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/801cyzdq6sza9",
  "venue": "Nature Communications",
  "versions": []
}