{
  "abstract": "Background: Extrachromosomal circular DNA (eccDNA) represents a pervasive structural continuum of genomic instability that drives intratumoral heterogeneity; the topography of the eccDNA-encoded non-coding transcriptome remains obscure in ultraviolet (UV)-driven malignancies.\n\nMethods: We profiled eccDNA from Basal Cell Carcinoma, Inverted Follicular Keratosis, Merkel Cell Carcinoma, and matched adjacent normal tissues using Circle-Seq. Structural data were integrated with the eccDNA Gene Analyzer (ECGA) and The Cancer Genome Atlas (TCGA) clinical cohorts. In vitro siRNA-mediated knockdown assays were used to determine the oncogenic functionality of identified lncRNAs.\n\nResults: Circle-Seq revealed genome-wide remodeling of circular DNA with focal hyper-amplification, GC-rich compositional biases, and recurrent hotspots on chromosomes 9, 16, and 20. Integrative screening identified AGAP2-AS1 as a clinically significant, copy-number-associated lncRNA, whose expression correlated with cellular responses to UV radiation and oxidative stress. Depletion of AGAP2-AS1 impaired tumor cell proliferation, migration, and invasion in vitro.\n\nConclusion: The eccDNA landscape serves as a reservoir of functional non-coding elements; focal amplification of AGAP2-AS1 contributes to malignant progression and stress adaptation in cutaneous neoplasia.",
  "abstract_shown": true,
  "affiliations": [
    "Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital",
    "Department of Ophthalmology, The First Hospital of Hohhot",
    "Tumor Multimodal Digital and Intelligent Precision Diagnosis Engineering Research Center, School of Basic Medical Sciences, Inner Mongolia Medical University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jin Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zeying Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinzhi Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xun Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhiying Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Huiting Xue"
    },
    {
      "affs": [
        0
      ],
      "name": "Tingting Lin"
    },
    {
      "affs": [
        0
      ],
      "name": "Limin Zhu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8057698m78jyj.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1906797",
  "fulltext_url": "https://europepmc.org/articles/PMC13713694",
  "id": "8057698m78jyj",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1906797/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "1306|Cancer-related molecular mechanisms research"
    ]
  ],
  "openalex": "W7221787920",
  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1906797/pdf",
  "pmcid": "PMC13713694",
  "pmid": "42953000",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/8057698m78jyj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1906797",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1906797/full"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953000",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953000"
    },
    {
      "first_seen": "2026-10-31T12:24:12Z",
      "native_id": "PMC13713694",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fphar.2026.1906797"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Cancer-related molecular mechanisms research",
      "subfield": "oncology"
    }
  ],
  "title": "Extrachromosomal circular DNA drives focal amplification of AGAP2-AS1 to promote cutaneous tumorigenesis",
  "title_text": "Extrachromosomal circular DNA drives focal amplification of AGAP2-AS1 to promote cutaneous tumorigenesis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:19Z",
  "url": "https://research.draconitic.com/paper/8057698m78jyj",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}