{
  "abstract": "Adherent cells must continuously adapt to rapid environmental fluctuations to preserve mechanical integrity. However, conventional theoretical frameworks predominantly rely on quasi-static assumptions, thereby limiting their ability to capture the transient dynamics of cellular responses to high-rate perturbations, such as acute osmotic shocks. To address this limitation, we developed a biophysical model incorporating a Hill-type law that couples active cytoskeletal mechanics to cell-edge velocity, explaining the counterintuitive experimental observation that traction forces transiently decrease during rapid hypotonic swelling despite an increase in cell size. We further construct a kinematic-geometric phase diagram that connects classical quasi-static theories with our dynamic model. Moreover, we show that traction-force dynamics are sensitive to the loading rate and amplitude of osmotic shock. In addition, stiffness-associated simulations and supporting perturbation evidence suggest a cellular stiffness-associated recovery trend in which stiffer cells exhibit faster volume recovery driven by stronger recoil of hydrostatic pressure.",
  "abstract_shown": true,
  "affiliations": [
    "university of science and technology of china"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "j. gan"
    },
    {
      "name": "x. wang"
    },
    {
      "affs": [
        0
      ],
      "name": "w. wu"
    },
    {
      "name": "s. zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "s. wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/806p6jj9s96an.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.21.715587",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.715587v1.full",
  "id": "806p6jj9s96an",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.715587v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biophysics"
    ],
    [
      "openalex",
      "1307|Cellular Mechanics and Interactions"
    ]
  ],
  "openalex": "W7214237487",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.715587v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/806p6jj9s96an.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:22Z",
      "native_id": "10.64898/2026.09.21.715587",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.715587v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biophysics",
      "subfield": "biophysics"
    }
  ],
  "title": "Kinematically-Dominated Regime Shapes Cell Traction Force Dynamics under Osmotic Shock",
  "title_text": "Kinematically-Dominated Regime Shapes Cell Traction Force Dynamics under Osmotic Shock",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:22Z",
  "url": "https://research.draconitic.com/paper/806p6jj9s96an",
  "venue": "bioRxiv",
  "versions": []
}