{
  "abstract": "PhenoAge, a blood-based biological aging clock, is associated with cancer outcomes, a finding taken as evidence that biological aging shapes prognosis. In 3,067 patients undergoing primary tumor resection, PhenoAge acceleration rose with tumor stage. One or two of its eight blood components, differing by cancer type, carried the prognostic signal, and replacing its general-population weights with equal weights did not weaken it. In cancer, PhenoAge may reflect disease burden rather than biological aging.",
  "abstract_shown": true,
  "affiliations": [
    "Memorial Sloan Kettering Cancer Center"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. K. Simhal"
    },
    {
      "name": "J. Lee"
    },
    {
      "name": "K. S. Tan"
    },
    {
      "name": "P. J. McCormick"
    },
    {
      "name": "G. W. Fischer"
    },
    {
      "name": "J. R. Scarpa"
    },
    {
      "name": "G. Sapiro"
    },
    {
      "name": "J. S. Mincer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/80gkphq7q9bsr.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.15.26365671",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365671v1.full",
  "id": "80gkphq7q9bsr",
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  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365671v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "oncology"
    ],
    [
      "openalex",
      "2717|Frailty in Older Adults"
    ]
  ],
  "openalex": "W7222980817",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365671v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/80gkphq7q9bsr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:10Z",
      "native_id": "10.64898/2026.10.15.26365671",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.15.26365671v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Blood-based PhenoAge may reflect disease burden rather than biological aging in cancer",
  "title_text": "Blood-based PhenoAge may reflect disease burden rather than biological aging in cancer",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:10Z",
  "url": "https://research.draconitic.com/paper/80gkphq7q9bsr",
  "venue": "medRxiv",
  "versions": []
}