{
  "abstract": "Background: Routine platelet indices reflect platelet size and turnover, whereas soluble vascular cell adhesion molecule-1 (sVCAM-1) reflects endothelial activation. Whether these inexpensive indices relate to circulating VCAM-1 in coronary artery disease (CAD) is unclear.\n\nObjective: To evaluate the association between platelet indices and sVCAM-1 in patients with CAD.\n\nMethods: This cross-sectional study consecutively enrolled 80 patients with stable, angiographically confirmed CAD (>50% stenosis in at least one major coronary artery) at Dr. Kariadi General Hospital, Semarang, Indonesia. Platelet count, mean platelet volume (MPV), platelet large cell ratio (P-LCR) and large-platelet count were measured with a Sysmex XN-1000 analyser, and serum sVCAM-1 by sandwich ELISA (Elabscience). Spearman correlation and multivariable linear regression were used.\n\nResults: Platelet count (ρ = 0.24, p = 0.036) and large-platelet count (ρ = 0.35, p = 0.002) were weakly correlated with sVCAM-1 (344.23 ± 144.98 ng/mL), whereas MPV (ρ = 0.10, p = 0.387) and P-LCR (ρ = 0.11, p = 0.336) were not. After adjustment for clinical covariates, only large-platelet count remained associated with sVCAM-1 (β = 58.7 ng/mL per SD; 95% CI 23.4–94.1; p = 0.002).\n\nConclusion: In stable CAD, large-platelet count and, less robustly, platelet count, but not MPV or P-LCR, were weakly associated with sVCAM-1. These hypothesis-generating findings require confirmation in larger prospective studies.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral study Program of Medical and Health Science, Faculty of Medicine, Diponegoro University, Indonesia",
    "Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Indonesia",
    "Department of Cardiology and Vascular Medicine, Faculty of Medicine, Diponegoro University, Indonesia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ariosta"
    },
    {
      "affs": [
        1
      ],
      "name": "Banundari Rachmawati"
    },
    {
      "affs": [
        2
      ],
      "name": "Udin Bahrudin"
    },
    {
      "affs": [
        1
      ],
      "name": "N.S. Widyastiti"
    },
    {
      "affs": [
        1
      ],
      "name": "Dwi Retnoningrum"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/80nycegk7nwwk.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ahjo.2026.100960",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733414/",
  "id": "80nycegk7nwwk",
  "issns": [
    "2666-6022"
  ],
  "landing_url": "https://doi.org/10.1016/j.ahjo.2026.100960",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Paper"
    ],
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7221801622",
  "pdf_url": null,
  "pmcid": "PMC13733414",
  "pmid": "42985130",
  "published": "2026-10-14",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/80nycegk7nwwk.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:23:11Z",
      "native_id": "PMC13733414",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ahjo.2026.100960"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Association between platelet indices and VCAM-1 levels in patients with coronary artery disease",
  "title_text": "Association between platelet indices and VCAM-1 levels in patients with coronary artery disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:11Z",
  "url": "https://research.draconitic.com/paper/80nycegk7nwwk",
  "venue": "American Heart Journal Plus: Cardiology Research and Practice",
  "versions": []
}