{
  "abstract": "The one-pot synthesis and electrospinning of cellulose derivatives bearing pseudo-peptide pendants, which are expected to serve as novel chiral recognition materials, are reported. Ugi four-component reactions (U-4CRs) involving carboxymethyl cellulose (CMC), formaldehyde, a glycine-based isocyanide (ethyl isocyanoacetate), and six different amino acid methyl esters as the carboxylic acid, aldehyde, isocyanide, and amine components, respectively, were employed to introduce pseudo-peptide pendants onto the cellulose backbone. The reactions proceeded successfully under weakly acidic conditions (pH 4), yielding derivatives with degrees of substitution (DSs) of 0.37−0.44, whereas reactions at pH 1−3 and 5 were hindered by competing side reactions. The derivatives were characterized by FTIR, NMR, size-exclusion chromatography, and elemental analysis. Furthermore, they were successfully electrospun using poly(ethylene oxide) as a carrier polymer, producing uniform and continuous nanofibers. These results demonstrate the feasibility of combining U−4CR with electrospinning to fabricate functional cellulose-based nanofibrous materials for potential chiral recognition applications.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Steve Nono-Tagne"
    },
    {
      "name": "Minoru Kuroiwa"
    },
    {
      "name": "Mihaela Ciorescu"
    },
    {
      "name": "Maëlle Fischer"
    },
    {
      "name": "Isabelle Jeacomine"
    },
    {
      "name": "Jean-Luc Putaux"
    },
    {
      "name": "Yoshiharu Nishiyama"
    },
    {
      "name": "Atsushi Narumi"
    },
    {
      "name": "Ryohei Kakuchi"
    },
    {
      "name": "Issei Otsuka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/819x3f1g6pwn8.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.biomac.6c01517",
  "fulltext_url": null,
  "id": "819x3f1g6pwn8",
  "issns": [
    "1525-7797",
    "1526-4602"
  ],
  "landing_url": "https://hal.science/hal-05771981v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.mate"
    ],
    [
      "hal",
      "1.chim.poly"
    ],
    [
      "openalex",
      "2502|Advanced Cellulose Research Studies"
    ]
  ],
  "openalex": "W7214238220",
  "pdf_url": "https://hal.science/hal-05771981/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-24",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/819x3f1g6pwn8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:44Z",
      "native_id": "hal-05771981",
      "source": "hal",
      "url": "https://hal.science/hal-05771981v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.mate",
      "subfield": "materials-polymers"
    }
  ],
  "title": "One-Pot Synthesis and Electrospinning of Cellulose Derivatives Bearing Pseudo-Peptide Pendants via Ugi Four−Component Reaction for Functional Nanofiber Fabrication",
  "title_text": "One-Pot Synthesis and Electrospinning of Cellulose Derivatives Bearing Pseudo-Peptide Pendants via Ugi Four−Component Reaction for Functional Nanofiber Fabrication",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:44Z",
  "url": "https://research.draconitic.com/paper/819x3f1g6pwn8",
  "venue": "Biomacromolecules",
  "versions": []
}