{
  "abstract": ", and interferon response genes. PARP7i potentiated the immunogenic effects of hypofractionated radiation by inducing a STING-dependent IFN-I response, leading to immunogenic cell death and activation of monocytes and NK cells. Carbon ion irradiation elicited stronger immunogenicity than X-rays when combined with PARP7i. KRAS-mutated PANC-1 cells showed a higher expression of enzymes that convert ATP to immunosuppressive adenosine, which was enhanced by radiation. This may explain why PARP7i were more effective as monotherapy in PANC-1 cells, promoting NK cell activation. These findings support further evaluation of PARP7i in PDAC in combination with radiotherapy or as monotherapy, depending on the immunosuppressive effects of radiation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Niccolò Bragato"
    },
    {
      "name": "Ana Beatriz Dias"
    },
    {
      "name": "Anna Ohradanova-Repic"
    },
    {
      "name": "Alma Dupanovic"
    },
    {
      "name": "Filip Horvat"
    },
    {
      "name": "Patrick Fischer"
    },
    {
      "name": "Lisa-Marie Appel"
    },
    {
      "name": "Lena Walch"
    },
    {
      "name": "Ava Kleinwächter"
    },
    {
      "name": "Anna Röhrer"
    },
    {
      "name": "Sylvia Kerschbaum-Gruber"
    },
    {
      "name": "Sandra Barna"
    },
    {
      "name": "Piero Fossati"
    },
    {
      "name": "Dietmar Georg"
    },
    {
      "name": "Joachim Widder"
    },
    {
      "name": "Klaus Podar"
    },
    {
      "name": "Michael Cohen"
    },
    {
      "name": "Dea Slade"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/81x3nr2tdvtwm.bib",
  "cited_by": 0,
  "doi": "10.1016/j.omton.2026.201258",
  "fulltext_url": null,
  "id": "81x3nr2tdvtwm",
  "issns": [
    "2950-3299"
  ],
  "landing_url": "https://hal.science/hal-05787608v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2730|PARP inhibition in cancer therapy"
    ]
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  "openalex": "W7163915111",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/81x3nr2tdvtwm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:51Z",
      "native_id": "hal-05787608",
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      "url": "https://hal.science/hal-05787608v1"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|PARP inhibition in cancer therapy",
      "subfield": "oncology"
    }
  ],
  "title": "PARP7 inhibitors enhance the immunogenic effects of radiation in pancreatic cancer cells",
  "title_text": "PARP7 inhibitors enhance the immunogenic effects of radiation in pancreatic cancer cells",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:51Z",
  "url": "https://research.draconitic.com/paper/81x3nr2tdvtwm",
  "venue": "Molecular Therapy: Oncology",
  "versions": []
}