{
  "abstract": "Tumor-associated macrophages (TAMs) adapt to hypoxia, nutrient competition, lipid accumulation, and anticancer treatment. Mitochondria contribute to this adaptation through energy metabolism, redox signaling, mitochondrial DNA (mtDNA) sensing, and metabolite-dependent regulation of gene expression. This Review examines mitochondrial dynamics, mitophagy, proteostasis, respiratory remodeling, and lipid-droplet interactions, distinguishing direct TAM evidence from findings in other experimental systems. Tumor studies link these processes to IL-12 and IL-10 production, interferon responses, antigen presentation, and lymphocyte recruitment, with effects that vary by pathway and macrophage state. These findings do not establish a single optimal level of mitochondrial quality control. We discuss how macrophage lineage, spatial niche, and treatment exposure may influence the response to mitochondrial interventions. Therapeutic development will require causal validation in defined TAM populations, selective delivery, and measurements of immune function alongside mitochondrial changes. Evidence in human TAMs and direct studies of organelle contacts remain limited. Somatic mtDNA variation is considered separately from altered gene expression and DNA release, with lineage-tracing evidence distinguished from functional causation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University",
    "Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University",
    "The First School of Clinical Medicine, Southern Medical University",
    "The Second Affiliated Hospital of Guilin Medical University",
    "School of Basic Medical Sciences, Guangzhou University of Chinese Medicine",
    "Department of Nephrology and Rheumatology, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University",
    "Department of Radiology, the Second Affiliated Hospital, University of South China",
    "Department of Pharmacy, The Seventh Affiliated Hospital, Southern Medical University",
    "Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University",
    "Institute for Clinical Medical Research, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University"
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiabao Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yangtao Liu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Hongjie Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhao Yuan"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Sheng Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaodong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hanbin Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Fei Zhong"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Xiong"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Xiaoling Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qingqing Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Jiani Liu"
    },
    {
      "affs": [
        5
      ],
      "name": "Li Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Qizhen Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Heying Yue"
    },
    {
      "affs": [
        6
      ],
      "name": "Liang Huang"
    },
    {
      "affs": [
        7
      ],
      "name": "Ning Zhu"
    },
    {
      "affs": [
        8
      ],
      "name": "Yi Yuan"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Meng Li"
    },
    {
      "affs": [
        9
      ],
      "name": "Chengkai Wu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/822rk6ffd7ycb.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1971517",
  "fulltext_url": "https://europepmc.org/articles/PMC13684806",
  "id": "822rk6ffd7ycb",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1971517/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Immune cells in cancer"
    ]
  ],
  "openalex": "W7220850174",
  "pdf_url": "https://europepmc.org/articles/PMC13684806?pdf=render",
  "pmcid": "PMC13684806",
  "pmid": "42909308",
  "published": "2026-10-07",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/822rk6ffd7ycb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1971517",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1971517/full"
    },
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909308",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909308"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immune cells in cancer",
      "subfield": "immunology"
    }
  ],
  "title": "Mitochondrial regulation of tumor-associated macrophage function",
  "title_text": "Mitochondrial regulation of tumor-associated macrophage function",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/822rk6ffd7ycb",
  "venue": "Frontiers in Immunology",
  "versions": []
}