{
  "abstract": "Purinergic signaling has been widely recognized as a critical regulator of tumor progression, yet the role of P2Y₁₄R in cervical cancer remains unclear. This study used the P2Y₁₄R antagonist PPTN in in vitro cell experiments; the results showed that it significantly inhibited cell proliferation and increased LDH release. The anti-tumor effect of P2Y₁₄R antagonism was further validated using a cervical cancer organoid model. Mechanistically, PPTN treatment elevated intracellular cAMP levels, enhanced the phosphorylation of PKA and CREB, and thereby activated the cAMP/PKA/CREB signaling axis. Moreover, PPTN intervention reduced Ki67 expression in cervical cancer organoids without affecting CK13 expression, suggesting that the anti-tumor effect of PPTN may not mediated through regulation of differentiation. Collectively, these findings identify P2Y₁₄R as a novel regulator of the cAMP/PKA/CREB signaling pathway in cervical cancer cells, providing a promising therapeutic target for cervical cancer.",
  "abstract_shown": true,
  "affiliations": [
    "International Joint Research Centre On Purinergic Signalling, School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.",
    "Sichuan Science City Hospital, Mianyang, 621999, China.",
    "International Joint Research Centre On Purinergic Signalling, School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. tangyong@cdutcm.edu.cn.",
    "International Joint Research Centre On Purinergic Signalling, School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. mawenbin@cdutcm.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rui Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Hai-Yun Xiong"
    },
    {
      "affs": [
        0
      ],
      "name": "Shi-Yu Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Yong Tang"
    },
    {
      "affs": [
        3
      ],
      "name": "Wen-Bin Ma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/826kfrs4sv9es.bib",
  "cited_by": 0,
  "doi": "10.1007/s11302-026-10192-0",
  "fulltext_url": "https://europepmc.org/articles/PMC13669287",
  "id": "826kfrs4sv9es",
  "issns": [
    "1573-9538",
    "1573-9546"
  ],
  "landing_url": "https://europepmc.org/article/MED/42873384",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1314|Adenosine and Purinergic Signaling"
    ]
  ],
  "openalex": "W7221780693",
  "pdf_url": "https://europepmc.org/articles/PMC13669287?pdf=render",
  "pmcid": "PMC13669287",
  "pmid": "42873384",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/826kfrs4sv9es.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:46Z",
      "native_id": "MED:42873384",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42873384"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1314|Adenosine and Purinergic Signaling",
      "subfield": "physiology"
    }
  ],
  "title": "Targeting P2Y₁₄R inhibits proliferation of cervical cancer cells and organoids and activates cAMP/PKA/CREB signaling pathway.",
  "title_text": "Targeting P2Y₁₄R inhibits proliferation of cervical cancer cells and organoids and activates cAMP/PKA/CREB signaling pathway.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:46Z",
  "url": "https://research.draconitic.com/paper/826kfrs4sv9es",
  "venue": "Purinergic signalling",
  "versions": []
}