{
  "abstract": "The plant hormone jasmonoyl-isoleucine (JA-Ile) reallocates resources from growth towards induced defenses upon microbial or herbivore attacks or other environmental threats. JA-Ile and its precursor jasmonic acid (JA) undergo complex enzymatic turnover that shape hormonal dynamics for optimal signaling. JA-Ile is inactivated through gradual oxidation by CYP94 monooxygenases, followed by 12-OH-JA-Ile deconjugation towards 12-OH-JA. 12-OH-JA was believed to originate also from direct JA hydroxylation by JAO/JOX dioxygenases. Here we investigate the nature and origins of hydroxy-JAs and their derivatives upon stress responses in Arabidopsis. Using a set of analytical methods to explore enzyme assays and multiple pathway-impaired mutants, we show that JAO enzymes produce exclusively 11-OH-JA rather than 12-OH-JA and define a separate branch in JA catabolism. Upon leaf wounding, the CYP94/AH and, to a lesser extent, the JAO pathways direct the respective accumulation of 12- and 11-OH-JAs and their 11/12-glucosylated and 12-sulfated derivatives with isoform-specific occurrences. In contrast, Botrytis infection triggers the exclusive accumulation of 11-OH-JA and 11-Glc-O-JA with complex patterns of HSO4-JA. Finally, treatment of jar1 seedlings with 11-OH-JA does not trigger transcriptional changes, reinforcing the notion that the JAO/11-OH-JA pathway represents a metabolic sink modulating JA-Ile formation. Our findings elucidate the 11-OH-JA biosynthetic pathway and highlight stress-specific hydroxylation signatures.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Thierry Heitz"
    },
    {
      "name": "Valentin Marquis"
    },
    {
      "name": "Julie Zumsteg"
    },
    {
      "name": "Katheline Baksic"
    },
    {
      "name": "Dina Dannawi"
    },
    {
      "name": "Simon Ndecky"
    },
    {
      "name": "Dorian Schutz"
    },
    {
      "name": "Laurence Miesch"
    },
    {
      "name": "Philippe Schaeffer"
    },
    {
      "name": "Pierre Adam"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/82fkr4jdhr027.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77608-8",
  "fulltext_url": null,
  "id": "82fkr4jdhr027",
  "issns": [
    "2041-1723",
    "2041-1723"
  ],
  "landing_url": "https://hal.science/hal-05753351v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1109|Insect-Plant Interactions and Control"
    ]
  ],
  "openalex": "W7212388910",
  "pdf_url": "https://hal.science/hal-05753351/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-12",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/82fkr4jdhr027.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:36Z",
      "native_id": "hal-05753351",
      "source": "hal",
      "url": "https://hal.science/hal-05753351v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1109|Insect-Plant Interactions and Control",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "The 11-hydroxy-jasmonic acid pathway expands jasmonate catabolic repertoire for stress-specific hormone attenuation in Arabidopsis",
  "title_text": "The 11-hydroxy-jasmonic acid pathway expands jasmonate catabolic repertoire for stress-specific hormone attenuation in Arabidopsis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:36Z",
  "url": "https://research.draconitic.com/paper/82fkr4jdhr027",
  "venue": "Nature Communications",
  "versions": []
}