{
  "abstract": "Perineuronal nets (PNNs) regulate synaptic stabilization and neural circuit development in the central nervous system. Although BCAN-associated extracellular matrix specializations have been described in the cochlea, their developmental organization and response to acoustic injury remain poorly understood. Here we characterized BCAN-associated extracellular matrix in the developing and adult mouse cochlea and examined changes following noise-induced hearing loss (NIHL). HAPLN1 and neurocan were broadly detected around inner hair cells from postnatal day 7 (P7), whereas BCAN immunoreactivity was not detected at P7 but was detectable around the inner hair cell (IhC) region at P14. RNA in situ hybridization and exploratory analysis of published single-cell transcriptomic datasets characterized developmental patterns of BCAN mRNA signals in spiral ganglion-associated cell populations. Three-dimensional cochlear clearing and light-sheet imaging qualitatively revealed BCAN immunoreactivity surrounding a subset of cell bodies in the auditory nerve transitional region of adult cochleae. Following permanent-threshold-shift–inducing noise exposure, BCAN immunoreactivity was markedly reduced in the IhC region and appeared less prominent around cell bodies in the auditory nerve transitional region. These findings further characterize BCAN-associated extracellular matrix patterns in the mouse cochlea and describe developmental changes in BCAN immunoreactivity and its reduction following severe NIHL.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "So Young Kim"
    },
    {
      "name": "Nuri Jin"
    },
    {
      "name": "Ho Sun Lee"
    },
    {
      "name": "Min-Hyun Park"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/82hnz6y1pevf4.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-75639-1",
  "fulltext_url": null,
  "id": "82hnz6y1pevf4",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-75639-1",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2809|Hearing, Cochlea, Tinnitus, Genetics"
    ]
  ],
  "openalex": "W7221672381",
  "pdf_url": "https://www.nature.com/articles/s41598-026-75639-1_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-13",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/82hnz6y1pevf4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:26Z",
      "native_id": "10.1038/s41598-026-75639-1",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-75639-1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2809|Hearing, Cochlea, Tinnitus, Genetics",
      "subfield": "neuroscience"
    }
  ],
  "title": "Brevican immunoreactivity in the mouse cochlea during development and following noise-induced hearing loss",
  "title_text": "Brevican immunoreactivity in the mouse cochlea during development and following noise-induced hearing loss",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:26Z",
  "url": "https://research.draconitic.com/paper/82hnz6y1pevf4",
  "venue": "Scientific Reports",
  "versions": []
}