{
  "abstract": "Objective: To investigate the high-risk factors associated with the persistence or progression of cervical intraepithelial neoplasia 2 (CIN2) to cervical intraepithelial neoplasia 3 (CIN3) in women of childbearing age undergoing conservative management, thereby providing guidance for selecting appropriate treatment strategies for women with CIN2 who wish to preserve their fertility.\n\nMethods: Univariate and multivariate logistic regression analyses were performed using the clinical and pathological characteristics of the included patients to identify high-risk factors associated with the persistence or progression of CIN2.\n\nResults: In total, 226 patients were included in this study. Of these, 142 (62.8%) experienced lesion regression, 58 (25.7%) had persistent CIN2, and 26 (11.5%) progressed to CIN3. Univariate analysis indicated that age, high- squamous intraepithelial lesion (HSIL), human papillomavirus type 16/18 (HPV16/18) positivity, and P16/Ki-67 positivity were associated with persistence of CIN2 or progression to CIN3. Multivariate analysis revealed that age of >35 years (OR 2.732, 95% CI 1.350–5.529), HPV16/18 positivity (OR 1.506, 95% CI 1.129–17.611), HSIL (OR 4.693, 95% CI 3.554–19.211), and P16/Ki-67 positivity (OR 4.007, 95% CI 2.819–6.014) were associated with persistence or progression of CIN2.\n\nConclusion: Age of >35 years, HPV16/18 positivity, HSIL, and P16/Ki-67 positivity are associated with persistence and progression of CIN2. Conservative management with outpatient follow-up is an appropriate treatment option for carefully selected patients without these high-risk factors.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital",
    "Department of Gastrointestinal Surgery, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People’s Hospital, Chengdu Second People’s Hospital"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Meilian Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Gang Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongmei Xiao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingxue Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yixue Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuelian Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Limei Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Haixia Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/82jqqxd12w42c.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1961644",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731372/",
  "id": "82jqqxd12w42c",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1961644/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Cervical Cancer and HPV Research"
    ]
  ],
  "openalex": "W7223113581",
  "pdf_url": "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1961644/pdf",
  "pmcid": "PMC13731372",
  "pmid": "42984903",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/82jqqxd12w42c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:24Z",
      "native_id": "10.3389/fpubh.2026.1961644",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1961644/full"
    },
    {
      "first_seen": "2026-11-08T12:21:35Z",
      "native_id": "PMC13731372",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fpubh.2026.1961644"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Cervical Cancer and HPV Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "High-risk factors associated with persistence and progression of cervical intraepithelial neoplasia 2 in women of reproductive age undergoing conservative management: a retrospective analysis",
  "title_text": "High-risk factors associated with persistence and progression of cervical intraepithelial neoplasia 2 in women of reproductive age undergoing conservative management: a retrospective analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:35Z",
  "url": "https://research.draconitic.com/paper/82jqqxd12w42c",
  "venue": "Frontiers in Public Health",
  "versions": []
}