{
  "abstract": "Prostate cancer progression is accompanied by dynamic remodeling of malignant cell states, whose metastatic potential and regulatory programs remain poorly defined. Here, we integrated single-cell, spatial, bulk transcriptomic, epigenomic, and experimental data to characterize malignant cell state transitions and identify candidate regulators associated with metastatic progression. A distinct intermediate state exhibits increased copy-number alterations, stemness, proliferation, and MYC activity, together with the highest transcriptional similarity to metastatic tumor cells, and is therefore designated as a metastasis-initiating-like (MIC-like) state. Transcriptional and regulon dynamics along the malignant cell state trajectory highlight FEV as a prominent candidate associated with the MIC-like state, with concordant expression and regulon activity patterns. Functionally, FEV is associated with a hybrid epithelial-mesenchymal phenotype, and its perturbation disrupts this phenotype, accompanied by reduced epithelial and mesenchymal features as well as impaired prostate cancer cell migration and invasion. Beyond this tumor-intrinsic feature, FEV is also associated with reduced cytotoxicity and interferon responses in the tumor microenvironment through its regulation of MIF-family genes. In addition to its potential roles in tumor cell plasticity and immune remodeling, FEV shows a reciprocal association with androgen signaling and distinct expression patterns across treatment response groups, highlighting its potential relevance in therapeutic contexts.",
  "abstract_shown": true,
  "affiliations": [
    "Xidian University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "S. Wu"
    },
    {
      "name": "J. Wei"
    },
    {
      "name": "X. Shi"
    },
    {
      "name": "X. Liu"
    },
    {
      "name": "X. zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "L. Huang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/82nrz54h81dhe.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.23.753952",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753952v1.full",
  "id": "82nrz54h81dhe",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753952v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "2740|Prostate Cancer Treatment and Research"
    ]
  ],
  "openalex": "W7214767640",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753952v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/82nrz54h81dhe.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:25:15Z",
      "native_id": "10.64898/2026.09.23.753952",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753952v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "An FEV-Associated Metastasis-Initiating-Like State Linked to Tumor Cell Plasticity and Immune Niche Remodeling in Prostate Cancer",
  "title_text": "An FEV-Associated Metastasis-Initiating-Like State Linked to Tumor Cell Plasticity and Immune Niche Remodeling in Prostate Cancer",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:15Z",
  "url": "https://research.draconitic.com/paper/82nrz54h81dhe",
  "venue": "bioRxiv",
  "versions": []
}