{
  "abstract": "Whether the oxidative balance score (OBS) and complete blood count (CBC)-derived inflammatory indices are associated with current asthma, relative to a correctly defined never-asthma comparison group and accounting for the survey's complex sampling design, has not been investigated. This cross-sectional study used data from a nationally representative health survey cycle (August 2021-August 2023). Current asthma (n = 517) and never-asthma (n = 3725) groups were defined using validated lifetime-diagnosis and current-status questions; a former-asthma group (n = 308) was analyzed descriptively. Six CBC-derived indices (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammatory response index, eosinophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio) were calculated from absolute blood counts. Survey-weighted logistic regression, incorporating NHANES sampling weights, stratification, and primary sampling units, estimated odds ratios (ORs) for current asthma per 1-standard deviation increase in OBS and each index, with exposure-specific covariate adjustment and Benjamini-Hochberg false discovery rate correction across the 6-index panel. Current-asthma participants had lower OBS (18.7 ± 6.9 vs 20.4 ± 6.9) than never-asthma participants and numerically higher values across all 6 inflammatory indices and high-sensitivity C-reactive protein (hsCRP), reaching unadjusted significance for OBS, systemic immune-inflammation index, eosinophil-to-lymphocyte ratio, and hsCRP. In survey-weighted models, OBS remained associated with lower odds of current asthma (OR 0.77, 95% confidence interval 0.68-0.87), and all 6 inflammatory indices remained associated with higher odds (ORs 1.12-1.32), surviving FDR correction (all q < .05). The OBS association was consistent in a 2-day dietary sensitivity analysis, while inflammatory-index estimates were materially unchanged after additional adjustment for race/ethnicity. hsCRP was not associated with asthma status after adjustment. Within the current-asthma group, OBS was not associated with CBC-derived inflammatory indices, although hsCRP differed across OBS quartiles in a secondary analysis (FDR q = .041). Lower OBS and higher levels of several CBC-derived inflammatory indices were each associated with current asthma compared with never-asthma status; however, OBS was not associated with inflammatory index levels within the current-asthma group. These cross-sectional associations do not establish causality but support prospective investigation of dietary and lifestyle antioxidant status and systemic inflammatory indices as correlates of asthma.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chest Diseases, Division of Allergy and Clinical Immunology, Trakya University Faculty of Medicine, Edirne, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ece Celik",
      "orcid": "0000-0003-1414-9423"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/82pcfdjz8jbg8.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051188",
  "fulltext_url": "https://europepmc.org/articles/PMC13681134",
  "id": "82pcfdjz8jbg8",
  "issns": [
    "0304-5412",
    "1536-5964"
  ],
  "landing_url": "https://europepmc.org/article/MED/42888586",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7222681562",
  "pdf_url": "https://europepmc.org/articles/PMC13681134?pdf=render",
  "pmcid": "PMC13681134",
  "pmid": "42888586",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/82pcfdjz8jbg8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42888586",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42888586"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "Lower oxidative balance score and higher systemic immune-inflammatory indices are associated with current asthma: A cross-sectional study.",
  "title_text": "Lower oxidative balance score and higher systemic immune-inflammatory indices are associated with current asthma: A cross-sectional study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/82pcfdjz8jbg8",
  "venue": "Medicine",
  "versions": []
}