{
  "abstract": "Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is associated with a high mortality rate. Although mesenchymal stem cell (MSC) therapy markedly improves liver function and survival in patients with HBV-ACLF, it remains unclear whether the immunomodulatory effects of MSCs suppress antiviral CD8⁺ T cell function and trigger HBV reactivation. Here, we developed a novel in vitro HBV-specific CD8⁺ T cell–mediated acute liver injury organoid model, which was co-cultured with either menstrual blood-derived MSCs (MenSCs) or umbilical cord-derived MSCs (UC-MSCs). We found that both MenSCs and UC-MSCs coordinate liver repair and antiviral immunity through precise immunomodulation, primarily via paracrine signaling. Both MSC types significantly downregulated pro-inflammatory (IFN-γ, TNF-α, IL-8, and CXCL10) and apoptosis-related genes (FasL and CASP7), while promoting hepatic regeneration through IL-6 and HGF upregulation, without compromising CD8⁺ T cell-mediated HBV clearance. This study provides critical insights into the safety of MSC therapy for HBV-ACLF.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology",
    "Department of Hepato-Biliary Surgery, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology",
    "State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xingxing Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhiwei Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Qibin Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yanhong Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Shumin Liao"
    },
    {
      "affs": [
        0
      ],
      "name": "Liang Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/82vjkmct7qhwn.bib",
  "cited_by": 0,
  "doi": "10.1186/s13287-026-05105-2",
  "fulltext_url": "https://doi.org/10.1186/s13287-026-05105-2",
  "id": "82vjkmct7qhwn",
  "issns": [
    "1757-6512"
  ],
  "landing_url": "https://doi.org/10.1186/s13287-026-05105-2",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QD415-436"
    ],
    [
      "lcc",
      "R5-920"
    ],
    [
      "openalex",
      "2716|Mesenchymal stem cell research"
    ]
  ],
  "openalex": "W7171366682",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/82vjkmct7qhwn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:42Z",
      "native_id": "38dd66b526814a2daf41db909dd6dccd",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s13287-026-05105-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Mesenchymal stem cell research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Precise immunomodulation by mesenchymal stem cells mitigates hepatitis B virus-specific CD8⁺ T cell-mediated acute liver injury without compromising viral clearance",
  "title_text": "Precise immunomodulation by mesenchymal stem cells mitigates hepatitis B virus-specific CD8⁺ T cell-mediated acute liver injury without compromising viral clearance",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:42Z",
  "url": "https://research.draconitic.com/paper/82vjkmct7qhwn",
  "venue": "Stem Cell Research & Therapy",
  "versions": []
}