{
  "abstract": "Heat-related mortality varies among individuals under similar environmental conditions, yet environmental exposure and genetic susceptibility are typically modelled separately. We propose a signal-processing cascade linking satellite-derived land-surface temperature to sequence-dependent heat-shock response and mortality risk. The framework combines distributed-lag filtering of thermal exposure, nonlinear HSF1 activation, cross-correlation with an HSF1 position-weight-matrix kernel, and Hill-model mapping of sequence-dependent binding changes to regulatory response. Applied to 52 heat-response genes and 157 naturally occurring variants, the framework identifies 21 heat-shock-element arrays across 17 genes. Variants in canonical arrays are significantly enriched for predicted binding disruption ($p=3\\times10^{-4}$). Propagating these effects through the cascade yields a peak predicted mortality-risk multiplier of $1.68\\times$ at $40$--$42\\,^{\\circ}\\mathrm{C}$. The framework demonstrates how environmental and genomic signals can be integrated to model inter-individual variation in heat-related risk.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2611.03667",
  "author_total": 2,
  "authors": [
    {
      "name": "Usman Nazir"
    },
    {
      "name": "Sara Khalid"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/832he92nss50b.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2611.03667",
  "fulltext_url": null,
  "id": "832he92nss50b",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2611.03667",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "cs.ET"
    ],
    [
      "arxiv",
      "stat.AP"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://arxiv.org/pdf/2611.03667",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/832he92nss50b.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:21:34Z",
      "native_id": "2611.03667",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2611.03667"
    }
  ],
  "subjects": [
    {
      "field": "mathematics",
      "origin": "arxiv:stat.AP",
      "subfield": "statistics"
    }
  ],
  "title": "A signal-processing cascade linking satellite heat exposure, genomic variation, and mortality risk",
  "title_text": "A signal-processing cascade linking satellite heat exposure, genomic variation, and mortality risk",
  "type": "preprint",
  "updated_at": "2026-11-06T18:21:10Z",
  "url": "https://research.draconitic.com/paper/832he92nss50b",
  "venue": "arXiv",
  "versions": []
}