{
  "abstract": "A nickel-catalysed cross-electrophile coupling (XEC) of 2-halopyridines to form 2,2′-bipyridines and 2,2′-bisquinoline is presented using manganese as the reductant. The method tolerates electron-donating and electron-withdrawing groups around the heterocyclic ring and has been applied to the preparation of homo- and cross-coupled products, including competition experiments. Finally, scaling-up the reaction revealed certain practical considerations that led to deviation from the optimised conditions and provided preliminary mechanistic insights.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Queen Mary University of London Mile End London E1 4NS UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Haseeb Ur Rehman Shah",
      "orcid": "0000-0003-1087-7706"
    },
    {
      "affs": [
        0
      ],
      "name": "Mahzabin Ahmed"
    },
    {
      "affs": [
        0
      ],
      "name": "Urvati N. Dhirajlal"
    },
    {
      "affs": [
        0
      ],
      "name": "A. Yannic R. Werling",
      "orcid": "0000-0002-2992-4018"
    },
    {
      "affs": [
        0
      ],
      "name": "Edward A. Neal",
      "orcid": "0000-0002-5464-9097"
    },
    {
      "affs": [
        0
      ],
      "name": "Christopher R. Jones",
      "orcid": "0000-0002-3420-658X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/83jtqcg0h6yx7.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra08877e",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673143/?tool=EBI",
  "id": "83jtqcg0h6yx7",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13673143",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Catalytic Cross-Coupling Reactions"
    ]
  ],
  "openalex": "W7222497610",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673143/pdf/?tool=EBI",
  "pmcid": "PMC13673143",
  "pmid": "42891081",
  "published": "2026-10-16",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/83jtqcg0h6yx7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13673143",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13673143"
    },
    {
      "first_seen": "2026-11-01T12:23:40Z",
      "native_id": "PMC13673143",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra08877e"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic Cross-Coupling Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Nickel-catalysed synthesis of symmetrical and unsymmetrical 2,2′-bipyridines via cross-electrophile coupling (XEC) using manganese reductant",
  "title_text": "Nickel-catalysed synthesis of symmetrical and unsymmetrical 2,2′-bipyridines via cross-electrophile coupling (XEC) using manganese reductant",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:53Z",
  "url": "https://research.draconitic.com/paper/83jtqcg0h6yx7",
  "venue": "RSC advances",
  "versions": []
}