{
  "abstract": "Objective: This study aimed to investigate the haematological changes in children with Mycoplasma pneumoniae (MP) infection carrying the 2063/2064 mutation, providing a clinical reference for the early identification of drug-resistant MP.\n\nMethods: A retrospective study was conducted on 161 children diagnosed with MP infection via nucleic acid testing in our hospital in 2024, alongside 27 healthy controls. Based on the 2063/2064 mutation status, the MP group was divided into a mutation-undetected group (n = 27) and a mutation-detected group (n = 134). Haematological parameters and inflammatory indices at diagnosis were compared. Dynamic changes between the initial visit and diagnosis were analysed in 64 mutation-detected patients with complete paired data. Additional analyses included bootstrap resampling, post-hoc power assessment, exploratory ROC analysis, logistic regression and hospitalisation-stratified sensitivity analysis.\n\nResults: No significant differences were observed between the mutation-detected and mutation-undetected groups in clinical characteristics or haematological and inflammatory indices at diagnosis (all p > 0.05). Among the 64 mutation-detected patients with complete paired measurements, MLR decreased from 0.32 (0.24, 0.48) at the initial visit to 0.27 (0.19, 0.37) at diagnosis (p = 0.004). In the hospitalisation-stratified analysis, this decline was significant among hospitalised patients but not among non-hospitalised patients. Exploratory ROC analysis showed limited discriminatory performance for both the directional MLR change (AUC = 0.508, 95% CI 0.344–0.672) and its absolute magnitude (AUC = 0.523, 95% CI 0.349–0.699).\n\nConclusion: Static haematological parameters and inflammatory indices did not distinguish mutation-detected from mutation-undetected MP infection. Although MLR decreased over time in the mutation-detected subgroup, ROC and stratified analyses showed that this change had limited discriminatory performance when used alone and may have been influenced by hospitalisation-related clinical factors. Dynamic MLR change should therefore be considered an exploratory marker requiring prospective validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, The Fourth Affiliated Hospital of Soochow University, Suzhou, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuanyuan Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tao Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Changyu Fu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaofang Yan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/83w2m9neyt4mb.bib",
  "cited_by": 0,
  "doi": "10.3389/fped.2026.1854263",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731215/",
  "id": "83w2m9neyt4mb",
  "issns": [
    "2296-2360"
  ],
  "landing_url": "https://doi.org/10.3389/fped.2026.1854263",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2404|Microbial infections and disease research"
    ]
  ],
  "openalex": "W7223154923",
  "pdf_url": "https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1854263/pdf",
  "pmcid": "PMC13731215",
  "pmid": "42984755",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/83w2m9neyt4mb.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:27Z",
      "native_id": "PMC13731215",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fped.2026.1854263"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2404|Microbial infections and disease research",
      "subfield": "microbiology"
    }
  ],
  "title": "Analysis of early haematological warning indicators for drug-resistant Mycoplasma pneumoniae infection",
  "title_text": "Analysis of early haematological warning indicators for drug-resistant Mycoplasma pneumoniae infection",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:27Z",
  "url": "https://research.draconitic.com/paper/83w2m9neyt4mb",
  "venue": "Frontiers in Pediatrics",
  "versions": []
}