{
  "abstract": "Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder marked by pancytopenia and marrow hypoplasia. As a promising therapeutic option, haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is still limited by graft rejection and delayed immune reconstitution, which can be effectively mitigated by mesenchymal stem cell (MSC) coinfusion. Here, we demonstrated that haplo-HSCT significantly restored the proportion and immunosuppressive capacity of bone marrow myeloid-derived suppressor cells (MDSCs) in SAA patients, and DECTIN1 ⁺ MDSCs emerged as central immunoregulators. MSC coinfusion further enhanced this effect. Mechanistically, MSC-derived exosomal ANXA2 upregulated DECTIN1 expression in MDSCs, which in turn activated STAT3 signaling to increase TNFAIP3 expression, thereby suppressing inflammatory T-cell responses. These changes were also reflected in peripheral blood. Human bone marrow organoid experiments confirmed that MSC coinfusion promoted DECTIN1 ⁺ MDSC expansion and accelerated bone marrow microenvironment recovery. Our findings revealed a previously unrecognized MSC-mediated mechanism and highlighted DECTIN1 ⁺ MDSCs as key immunoregulatory mediators and potential therapeutic targets in SAA.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Fu-Hao Yu",
      "orcid": "0009-0000-1178-6086"
    },
    {
      "name": "Gui-Yan Jia"
    },
    {
      "name": "Pei-Lin Li"
    },
    {
      "name": "Shuang Xia"
    },
    {
      "name": "Rui-Cong Hao"
    },
    {
      "name": "Heng-Xiang Wang"
    },
    {
      "name": "Dai-Hong Liu",
      "orcid": "0000-0003-3334-9113"
    },
    {
      "name": "Heng Zhu",
      "orcid": "0000-0002-8408-3821"
    },
    {
      "name": "Li Ding",
      "orcid": "0000-0001-9460-9201"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/847z5cq8ajxfe.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11246-0",
  "fulltext_url": null,
  "id": "847z5cq8ajxfe",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11246-0",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/847z5cq8ajxfe.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T15:20:14Z",
      "native_id": "10.1038/s42003-026-11246-0",
      "source": "feed-nature",
      "url": "https://www.nature.com/articles/s42003-026-11246-0"
    },
    {
      "first_seen": "2026-11-07T00:20:51Z",
      "native_id": "10.1038/s42003-026-11246-0",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11246-0"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "DECTIN1⁺ myeloid-derived suppressor cells mediate therapeutic effect of MSCs in haplo-HSCT for severe aplastic anemia",
  "title_text": "DECTIN1⁺ myeloid-derived suppressor cells mediate therapeutic effect of MSCs in haplo-HSCT for severe aplastic anemia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T00:20:59Z",
  "url": "https://research.draconitic.com/paper/847z5cq8ajxfe",
  "venue": "Communications Biology",
  "versions": []
}