{
  "abstract": "How nonenveloped viruses cross host membranes without causing cell lysis remains a central biophysical paradox. A recent cryogenic electron tomography study by de Sautu et al. proposed that rhesus rotavirus double-layered particles (DLPs) escape endocytic vesicles through a large, VP7-stabilized membrane pore. However, a static pore model is difficult to reconcile with live-cell single-particle tracking data showing multi-minute lags between VP7 dissociation and DLP release. Here, I show that these structural snapshots map onto the vesicle budding-and-collapse (VBC) framework, a recently discovered mechanism shared by a growing number of biological and synthetic membrane-translocation systems. Re-interpreting rotavirus entry through VBC resolves kinetic discrepancies in the literature and provides a unified physical paradigm for viral entry and drug delivery.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "name": "Dehua Pei",
      "orcid": "0000-0002-2057-6934"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/84ef4sy9r6zmc.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009704/v1",
  "fulltext_url": null,
  "id": "84ef4sy9r6zmc",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009704/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|Cellular transport and secretion"
    ]
  ],
  "openalex": "W7215109099",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009704/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/84ef4sy9r6zmc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009704",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009704/v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Cellular transport and secretion",
      "subfield": "cell-biology"
    }
  ],
  "title": "Decoding Rotavirus Cell Entry through the Lens of Vesicle Budding-and-Collapse",
  "title_text": "Decoding Rotavirus Cell Entry through the Lens of Vesicle Budding-and-Collapse",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/84ef4sy9r6zmc",
  "venue": "ChemRxiv",
  "versions": []
}