{
  "abstract": "Background. Alcohol use disorder (AUD) and cannabis use disorder (CUD) are often comorbid. Concurrent or simultaneous use of alcohol and cannabis is associated with poorer mental health outcomes in cross-sectional studies. Here, we examined whether lifetime history of comorbid AUD and CUD is associated with emotional well-being, above and beyond current substance use and lifetime major depression. Methods. Participants were 1,393 adults from the Collaborative Study on the Genetics of Alcohol Lifespan assessment (Mage= 52.0, 59.7% female). Emotional well-being was assessed across six domains from the NIH Toolbox Emotion Battery: loneliness, perceived stress, negative affect, social satisfaction, psychological well-being, and self-efficacy. Associations between lifetime diagnostic group (comorbid AUD + CUD, AUD without CUD, CUD without AUD, or neither disorder) and emotional well-being outcomes were assessed using multivariate linear regression. Covariates included age, sex, and past-year nicotine, cannabis, and alcohol use. Sensitivity analyses adjusted for lifetime major depressive disorder. Results. Individuals with comorbid lifetime AUD + CUD reported higher loneliness, perceived stress, and negative affect, and lower social satisfaction, psychological well-being, and self-efficacy compared to other groups. Individuals with lifetime AUD without CUD or CUD without AUD generally resembled those with neither disorder across several emotional well-being domains, though those in the AUD without CUD group reported greater negative affect and lower social satisfaction and psychological well-being than the group with neither disorder. Conclusions. A lifetime history of comorbid AUD and CUD is associated with diminished emotional well-being, underscoring the need for additional psychosocial supports to address these challenges in this population.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Fatima Hijazi"
    },
    {
      "name": "Jiawen Zhao"
    },
    {
      "name": "Megan Cooke"
    },
    {
      "name": "Sally I Kuo"
    },
    {
      "name": "Kathleen Bucholz"
    },
    {
      "name": "Grace Chan"
    },
    {
      "name": "Genevieve Fullerton Dash"
    },
    {
      "name": "Fanghong Dong"
    },
    {
      "name": "Christina Elizabeth Garasky"
    },
    {
      "name": "Chella Kamarajan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/84nnbm0nvj034.bib",
  "cited_by": 0,
  "doi": "10.31234/osf.io/jnbgt_v1",
  "fulltext_url": null,
  "id": "84nnbm0nvj034",
  "issns": [],
  "landing_url": "https://osf.io/preprints/psyarxiv/jnbgt_v1/",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "bepress",
      "Clinical Psychology"
    ],
    [
      "bepress",
      "Psychiatry"
    ],
    [
      "bepress",
      "Social and Behavioral Sciences"
    ],
    [
      "bepress",
      "Substance Abuse and Addiction"
    ],
    [
      "openalex",
      "2713|Substance Abuse Treatment and Outcomes"
    ]
  ],
  "openalex": "W7223227482",
  "pdf_url": "https://osf.io/jnbgt/download",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/84nnbm0nvj034.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:40Z",
      "native_id": "jnbgt",
      "source": "osf",
      "url": "https://osf.io/preprints/psyarxiv/jnbgt_v1/"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "bepress:Clinical Psychology",
      "subfield": "psychiatry"
    }
  ],
  "title": "Emotional Well-Being Among Adults with Comorbid Alcohol and Cannabis Use Disorders: Evidence from the COGA Lifespan Study",
  "title_text": "Emotional Well-Being Among Adults with Comorbid Alcohol and Cannabis Use Disorders: Evidence from the COGA Lifespan Study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:40Z",
  "url": "https://research.draconitic.com/paper/84nnbm0nvj034",
  "venue": "PsyArXiv",
  "versions": []
}