{
  "abstract": "Objectives:: To assess the safety and efficacy of intrathecal fluorescein administration during transmastoid repair of temporal lobe encephaloceles and identify predictors for intraoperative fluorescein identification.\n\nMethods:: This was a retrospective case-control study of consecutive adult patients with temporal lobe encephaloceles repaired via transmastoid approach from October 2012 to October 2024 at a single tertiary academic medical center. Medical records of qualifying patients were searched for demographics, diagnostic workup, disease characteristics, and intraoperative and postoperative outcomes. Analysis incorporated the Wilcoxon rank-sum, Pearson’s X2, and Fisher’s exact tests, along with unadjusted Kaplan-Meier estimates. Outcomes included encephalocele recurrence and symptomatic resolution rates, fluorescein complications, and rates and predictors of intraoperative fluorescein identification.\n\nResults:: 38 patients met inclusion criteria (age 59.8 + 11.9 years, BMI 35.8 + 8.7 kg/m2, 23 [60.5%] female). Recurrence (0% vs 11.5%, P = .54) and symptom resolution (83.3% vs 88.5%, P = .64) rates did not differ between patients who received and did not receive intrathecal fluorescein. No fluorescein-related complications were reported. Fluorescein was intraoperatively detected in six-twelfths cases, yielding a sensitivity of 50%. No demographic or clinical variables, including higher BMI, history of prior encephalocele, and size of largest defect, were associated with intraoperative fluorescein identification.\n\nConclusions:: Intrathecal fluorescein administration preliminarily appears to be a safe adjunctive tool to identify the leak source in the transmastoid repair of temporal lobe encephaloceles, but its risk-benefit ratio remains up for debate. Higher-powered studies are necessary to explore its utility in specific circumstances and to determine which patients may benefit most.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology – Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA",
    "Department of Otolaryngology – Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA",
    "Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Keshav V. Shah",
      "orcid": "0000-0003-3315-0665"
    },
    {
      "affs": [
        1
      ],
      "name": "Kevin Wong"
    },
    {
      "affs": [
        2
      ],
      "name": "Kim Le"
    },
    {
      "affs": [
        0
      ],
      "name": "Randall James Harley",
      "orcid": "0000-0002-8519-5366"
    },
    {
      "affs": [
        0
      ],
      "name": "Christian Jung"
    },
    {
      "affs": [
        0
      ],
      "name": "Tiffany Hwa"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael J. Ruckenstein"
    },
    {
      "affs": [
        0
      ],
      "name": "Douglas C. Bigelow"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/84qfffhdv2xsb.bib",
  "cited_by": 0,
  "doi": "10.1177/00034894261470543",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724808/",
  "id": "84qfffhdv2xsb",
  "issns": [
    "0003-4894",
    "1943-572X"
  ],
  "landing_url": "https://doi.org/10.1177/00034894261470543",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Articles"
    ],
    [
      "openalex",
      "2728|Neurosurgical Procedures and Complications"
    ]
  ],
  "openalex": "W7169791981",
  "pdf_url": null,
  "pmcid": "PMC13724808",
  "pmid": "42473798",
  "published": "2026-07-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/84qfffhdv2xsb.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:19Z",
      "native_id": "PMC13724808",
      "source": "pmc",
      "url": "https://doi.org/10.1177/00034894261470543"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Neurosurgical Procedures and Complications",
      "subfield": "neurology"
    }
  ],
  "title": "Utility of Intrathecal Fluorescein in Transmastoid Repair of Temporal Encephaloceles",
  "title_text": "Utility of Intrathecal Fluorescein in Transmastoid Repair of Temporal Encephaloceles",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:12Z",
  "url": "https://research.draconitic.com/paper/84qfffhdv2xsb",
  "venue": "The Annals of Otology, Rhinology, and Laryngology",
  "versions": []
}