{
  "abstract": "We report a rare case of granulocyte colony-stimulating factor (G-CSF)-producing lung adenocarcinoma with a high PD-L1 expression and a KRAS G12V mutation that responded to pembrolizumab. A 72-year-old man presented with leukocytosis, elevated serum G-CSF levels, a diffuse bone marrow fluorodeoxyglucose uptake, and a rapidly progressive lung mass. A biopsy revealed TTF-1 positive adenocarcinoma with a PD-L1 tumor proportion score of 100 % and a KRAS G12V mutation. Pembrolizumab induced marked tumor regression and normalization of the G-CSF levels. However, immune-related pneumonitis resulted in treatment discontinuation. Pembrolizumab may be effective in selected patients with G-CSF-producing lung cancer despite its typically aggressive clinical behavior.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Katsunori Arai"
    },
    {
      "name": "Hirokazu Tokuyasu"
    },
    {
      "name": "Shuichi Matsuoka"
    },
    {
      "name": "Hiromitsu Sakai"
    },
    {
      "name": "Chika Esumi"
    },
    {
      "name": "Akira Yamasaki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85078wbqygp58.bib",
  "cited_by": 1,
  "doi": "10.2169/internalmedicine.7754-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7754-26/_article",
  "id": "85078wbqygp58",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7754-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2730|Cancer Immunotherapy and Biomarkers"
    ]
  ],
  "openalex": "W7167932118",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7754-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/85078wbqygp58.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7754-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7754-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "A Case of Granulocyte Colony-Stimulating Factor-Producing Lung Adenocarcinoma with KRAS G12V Mutation Responding to Pembrolizumab",
  "title_text": "A Case of Granulocyte Colony-Stimulating Factor-Producing Lung Adenocarcinoma with KRAS G12V Mutation Responding to Pembrolizumab",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/85078wbqygp58",
  "venue": "Internal Medicine",
  "versions": []
}