{
  "abstract": "Background: The clinical characteristics of postural tachycardia syndrome patients with and without hypermobile Ehlers-Danlos syndrome remain unclear, particularly in the Japanese population. This study aimed to clarify the clinical features and laboratory findings of patients with postural tachycardia syndrome and hypermobile Ehlers-Danlos syndrome.\n\nMethods: We retrospectively analyzed patients who presented with orthostatic intolerance at our hospital between April 2023 and July 2025. Of these, 21 patients were diagnosed with postural tachycardia syndrome using the head-up tilt test. The clinical features and test results of these patients were compared to those of patients with and without hypermobile Ehlers-Danlos syndrome.\n\nResults: Of the 21 patients diagnosed with postural tachycardia syndrome, 4 were also found to have hypermobile Ehlers-Danlos syndrome. A significantly higher frequency of menstrual disorders was observed in the hypermobile Ehlers-Danlos syndrome group than in the non-hypermobile Ehlers-Danlos syndrome group (100% [4/4] vs. 23.1% [3/13], p = 0.015). Other clinical features and laboratory findings were similar between the groups.\n\nConclusion: These observations provide a rationale to hypothesize a possible contribution of connective tissue-related factors to disease progression. Larger studies are warranted to investigate whether a meaningful association exists between postural tachycardia syndrome and hypermobile Ehlers-Danlos syndrome.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medicine, Department of Neurology, University of Toyama",
    "Neuron-Glia Crosstalk Center, Graduate School of Medicine, Juntendo University",
    "Department of Medical Genetics, Shinshu University School of Medicine",
    "Department of Neurology, Takaoka Fushiki Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hiroaki Hirosawa"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shunya Nakane"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuhei Takasawa"
    },
    {
      "affs": [
        0
      ],
      "name": "Risako Furuta"
    },
    {
      "affs": [
        0
      ],
      "name": "Hiroki Maesaka"
    },
    {
      "affs": [
        0
      ],
      "name": "Taichi Mitsui"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryo Tanaka"
    },
    {
      "affs": [
        0
      ],
      "name": "Noriyuki Matsuda"
    },
    {
      "affs": [
        0
      ],
      "name": "Ryoko Shibuya"
    },
    {
      "affs": [
        0
      ],
      "name": "Mamoru Yamamoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomohiro Hayashi"
    },
    {
      "affs": [
        0
      ],
      "name": "Takamasa Nukui"
    },
    {
      "affs": [
        2
      ],
      "name": "Tomoki Kosho"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Yuji Nakatsuji"
    },
    {
      "affs": [
        0
      ],
      "name": "Toru Yamashita"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85acm71bmthqv.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1948115",
  "fulltext_url": null,
  "id": "85acm71bmthqv",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1948115/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/85acm71bmthqv.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T00:21:25Z",
      "native_id": "10.3389/fneur.2026.1948115",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1948115/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2295",
      "subfield": "neurology"
    }
  ],
  "title": "Clinical characteristics of postural tachycardia syndrome with and without hypermobile Ehlers-Danlos syndrome: a pilot study",
  "title_text": "Clinical characteristics of postural tachycardia syndrome with and without hypermobile Ehlers-Danlos syndrome: a pilot study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T00:23:06Z",
  "url": "https://research.draconitic.com/paper/85acm71bmthqv",
  "venue": "Frontiers in Neurology",
  "versions": []
}