{
  "abstract": "AIM: Reducing low-density lipoprotein cholesterol (LDL-C) levels is crucial for preventing atherosclerotic cardiovascular disease (ASCVD). Recommended lipid-lowering therapy (LLT) includes both oral (e.g., statins) and injectable agents. However, patient awareness of LDL-C management and adherence to it remain uncertain. METHODS: This cross-sectional study surveyed 415 Japanese patients with ASCVD using a web-based platform. The participants reported their understanding of LDL-C target values and the effects of LLT. Medication adherence was evaluated using the Extent of Nonadherence scale, and a binomial logistic regression analysis was performed to identify the factors associated with nonadherence. RESULTS: Approximately 58.1%-60.2% of the participants reported confidence in knowing their correct lipid target values and managing dyslipidemia appropriately. However, only 22.2% reported LDL-C targets of ＜50 or ＜70 mg/dL, and 43.4% believed their targets to be ＜50, ＜70, or ＜100 mg/dL. In contrast, 56.7% either reported LDL-C targets of ＜120, ＜140, or ＜160 mg/dL or did not know their targets. Regarding LLT, 65.8% were unaware that extreme lowering of LDL-C levels with LLT had no disadvantages, and 74.2% were unaware that injectable LLTs were available. Overall, 39.0% of the participants were nonadherent. Higher out-of-pocket costs (≥ 3,001 yen; adjusted odds ratio [OR]: 1.83, p = 0.024) and experience with self-injections (adjusted odds ratio: 2.34, p = 0.027) were significantly associated with nonadherence. CONCLUSIONS: Our findings highlight a considerable gap in patient knowledge and adherence to dyslipidemia management strategies. Interventions that promote patient education and shared decision-making are essential for improving adherence and achieving optimal LDL-C targets.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Mitsutoshi Toda"
    },
    {
      "name": "Kazuma Iekushi"
    },
    {
      "name": "Yuri Takahashi"
    },
    {
      "name": "Shun Kohsaka"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85bkkaj72h5pk.bib",
  "cited_by": 0,
  "doi": "10.5551/jat.66074",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66074/_article",
  "id": "85bkkaj72h5pk",
  "issns": [
    "1880-3873",
    "1340-3478"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66074/_article",
  "language": null,
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2714|Medication Adherence and Compliance"
    ]
  ],
  "openalex": "W7166874574",
  "pdf_url": "https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_66074/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/85bkkaj72h5pk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.5551/jat.66074",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/jat/33/11/33_66074/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "jstage-journal:medicine/cardiovascular",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Knowledge Gaps and Nonadherence Among Japanese Patients with Atherosclerotic Cardiovascular Disease",
  "title_text": "Knowledge Gaps and Nonadherence Among Japanese Patients with Atherosclerotic Cardiovascular Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:21Z",
  "url": "https://research.draconitic.com/paper/85bkkaj72h5pk",
  "venue": "Journal of Atherosclerosis and Thrombosis",
  "versions": []
}