{
  "abstract": "Integration of proteins into metal-organic frameworks (Protein@MOF) represents an effective method for protein stabilization, with rising demand across material and biomedical sciences. However, the molecular mechanism of protein-MOF interactions remains unsettled due to challenges in developing a general platform to systematically investigate such interactions, hindering improvements in their chemical and physical properties. Here, we develop a surfactant-guided strategy to modulate the assembly of protein@MOF through interfacial design. We discovered that the interfacial environment between proteins and MOFs is the primary factor determining encapsulation efficiency, structural retention, and functional performance. Lipid-based non-ionic surfactants such as glycerol monooleate (GMO) increase the protein's solvent-accessible surface area (SASA), suggesting partial remodeling of the protein surface and hydration shell. GMO at the interface of protein@MOF results in a 20% improvement in protein encapsulation and a 30% increase in MOF growth rate. All-atom molecular dynamics simulations reveal domain-specific interactions between GMO and flexible surface residues on protein in a concentration-dependent manner, involving both electrostatic and hydrophobic contacts. This work offers new molecular insights into how surfactant-driven interfacial design fine-tunes the stability of protein@MOF, laying the foundation for robust alternatives to lipid nanodiscs for membrane protein stabilization, and protein-based platforms for drug-delivery, biocatalysis, and biosensing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry and Biochemistry Texas Tech University Lubbock Texas USA",
    "Texas Tech University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ehsan Rashidniyaghi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mohammad Khavani",
      "orcid": "0000-0003-1883-8701"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Carlie Coerver"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ruibin Liang",
      "orcid": "0000-0001-8741-1520"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Raheleh Ravanfar",
      "orcid": "0000-0003-2992-0575"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85czmgs4ddz7v.bib",
  "cited_by": 5,
  "doi": "10.1002/advs.76011",
  "fulltext_url": null,
  "id": "85czmgs4ddz7v",
  "issns": [
    "2198-3844"
  ],
  "landing_url": "https://doi.org/10.1002/advs.76011",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1604|Metal-Organic Frameworks: Synthesis and Applications"
    ]
  ],
  "openalex": "W4416157792",
  "pdf_url": null,
  "pmcid": "PMC12642519",
  "pmid": "41292977",
  "published": "2026-06-09",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/85czmgs4ddz7v.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T13:20:46Z",
      "native_id": "W4416157792",
      "source": "openalex",
      "url": "https://doi.org/10.1002/advs.76011"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1604|Metal-Organic Frameworks: Synthesis and Applications",
      "subfield": "inorganic"
    }
  ],
  "title": "Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design",
  "title_text": "Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:04Z",
  "url": "https://research.draconitic.com/paper/85czmgs4ddz7v",
  "venue": "Advanced Science",
  "versions": []
}