{
  "abstract": "目的回顾分析住院患者尿培养病原菌分布与耐药特征，为尿路感染临床抗菌药物合理选用提供实验室依据。方法选择2022至2025年某医院住院患者送检的1902份尿培养标本，采用VITEK 2 Compact全自动微生物鉴定系统开展菌株鉴定，以MIC法为主、纸片扩散法与E-test法为辅完成药敏检测，依据CLSI 2024标准判读结果，WHONET 5.6及SPSS24.0软件完成数据分析。结果总计分离非重复病原菌678株，革兰阴性菌为优势菌群，大肠埃希菌占比最高（62.54%），其次为肺炎克雷伯菌（12.83%）；革兰阳性菌以粪肠球菌（4.72%）、屎肠球菌（1.62%）为主。大肠埃希菌对左氧氟沙星、磺胺甲噁唑、头孢呋辛酯、头孢曲松耐药率均>50%；肺炎克雷伯菌对左氧氟沙星等喹诺酮类、二代三代头孢菌素耐药率均>40%。统计学分析显示，两种革兰阴性菌在左氧氟沙星、磺胺甲噁唑等药物耐药率上差异有统计学意义（P<0.05）。粪肠球菌、屎肠球菌对红霉素、左氧氟沙星整体高耐药；屎肠球菌对氨苄西林耐药率显著高于粪肠球菌，组间差异具备统计学意义（P<0.001），万古霉素、利奈唑胺对两类肠球菌保持100%敏感。结论该院尿路感染病原菌以大肠埃希菌为主，临床常见喹诺酮类、头孢类药物耐药问题突出；肠球菌属氨苄西林耐药存在明显种间差异。需常态化开展细菌耐药监测，规范抗菌药物使用，强化耐药菌院内感控管理，遏制耐药菌株传播扩散。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "贾冰"
    },
    {
      "name": "张俏"
    },
    {
      "name": "李文玲"
    },
    {
      "name": "丛丹"
    },
    {
      "name": "庞超"
    },
    {
      "name": "王鹤"
    },
    {
      "name": "熊蔚蔚"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85hk26m8btyyg.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.009",
  "id": "85hk26m8btyyg",
  "issns": [
    "1007-4287"
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  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.009",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/85hk26m8btyyg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:47Z",
      "native_id": "acac6a8f29664c7b8a8d292268a74cb4",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.009"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "2022—2025年某院1902份尿培养检出病原菌分布及其耐药性分析",
  "title_text": "2022—2025年某院1902份尿培养检出病原菌分布及其耐药性分析",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:47Z",
  "url": "https://research.draconitic.com/paper/85hk26m8btyyg",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}