{
  "abstract": "Wide-field mid-infrared photothermal (MIP) imaging enables chemically specific microscopy with submicron spatial resolution but remains fundamentally limited by the trade-off between field of view, mid-infrared pulse energy, and spectral tunability. As a result, current wide-field implementations are typically restricted to fields of view below 200 μm and to either the fingerprint or high-wavenumber spectral regions. Here, we overcome these limitations by developing a wide-field fluorescence-detected mid-infrared photothermal (F-MIP) imaging platform driven by a commercial picosecond optical parametric oscillator (OPO). The system provides pulse energies of up to 360 μJ together with a broad tuning range from 625 to 4327 cm-1, enabling millimeter-scale wide-field imaging in the high-wavenumber regions. We demonstrate a field of view of approximately 1 mm in diameter for fluorescently labeled polystyrene beads while preserving spectral fidelity. Furthermore, the platform enables, to our knowledge, the first wide-field MIP imaging below 900 cm-1. To demonstrate its applicability to biomedical imaging, we performed large-area mosaic imaging of fluorescent tuberculosis-infected tissue sections, providing chemically resolved maps over millimeter-sized sample areas. These results establish broadly tunable OPO-driven F-MIP as a scalable platform for high-throughput vibrational imaging of large biological specimens and advanced materials.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2607.06208",
  "author_total": 5,
  "authors": [
    {
      "name": "Anooj Thayyil Raveendran"
    },
    {
      "name": "Supatcharee Cael"
    },
    {
      "name": "Anju Jose"
    },
    {
      "name": "Jürgen Popp"
    },
    {
      "name": "Christoph Krafft"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85hn0mafr3zst.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2607.06208",
  "fulltext_url": null,
  "id": "85hn0mafr3zst",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2607.06208",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.app-ph"
    ],
    [
      "arxiv",
      "physics.bio-ph"
    ],
    [
      "arxiv",
      "physics.ins-det"
    ],
    [
      "arxiv",
      "physics.optics"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://arxiv.org/pdf/2607.06208",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/85hn0mafr3zst.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:35:35Z",
      "native_id": "2607.06208",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2607.06208"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.app-ph",
      "subfield": "applied-instrumentation"
    },
    {
      "field": "physics",
      "origin": "arxiv:physics.bio-ph",
      "subfield": "biological-medical"
    },
    {
      "field": "physics",
      "origin": "arxiv:physics.optics",
      "subfield": "optics-photonics"
    }
  ],
  "title": "Millimeter-scale wide-field mid-infrared photothermal imaging enabled by a broadly tunable picosecond optical parametric oscillator",
  "title_text": "Millimeter-scale wide-field mid-infrared photothermal imaging enabled by a broadly tunable picosecond optical parametric oscillator",
  "type": "preprint",
  "updated_at": "2026-10-30T12:35:35Z",
  "url": "https://research.draconitic.com/paper/85hn0mafr3zst",
  "venue": "arXiv",
  "versions": [
    {
      "doi": "10.1021/cbmi.6c00154",
      "pid": null,
      "relation": "published-as",
      "title": null,
      "venue": null
    }
  ]
}