{
  "abstract": "Synapse loss is a defining feature of neurodegenerative disease, yet the signals that orchestrate synaptic elimination remain incompletely understood. Crowley and colleagues uncover an unexpected link between neuronal hyperactivity and adaptive immunity, showing that antibody-secreting B cells and immunoglobulins can drive complement-dependent synapse loss.",
  "abstract_shown": true,
  "affiliations": [
    "Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA",
    "Abrams Research Center on Neurogenomics, Northwestern University, Chicago, IL, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Terry R. Suk"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "David Gate",
      "orcid": "0000-0003-0481-9657"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85kcrs2vfskpz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.tips.2026.09.004",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13712219/",
  "id": "85kcrs2vfskpz",
  "issns": [
    "0165-6147",
    "1873-3735"
  ],
  "landing_url": "https://doi.org/10.1016/j.tips.2026.09.004",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2808|Neuroinflammation and Neurodegeneration Mechanisms"
    ]
  ],
  "openalex": "W7214084706",
  "pdf_url": null,
  "pmcid": "PMC13712219",
  "pmid": "42778424",
  "published": "2026-09-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/85kcrs2vfskpz.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:51Z",
      "native_id": "PMC13712219",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.tips.2026.09.004"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neuroinflammation and Neurodegeneration Mechanisms",
      "subfield": "neurology"
    }
  ],
  "title": "B cells enter the synaptic conversation",
  "title_text": "B cells enter the synaptic conversation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:51Z",
  "url": "https://research.draconitic.com/paper/85kcrs2vfskpz",
  "venue": "Trends in pharmacological sciences",
  "versions": []
}