{
  "abstract": "Purpose of review\n\nTraumatic brain injury is a highly prevalent condition impacting youth that commonly results in persist headache. However, current management is limited by our ability to differentiate youth who will recover with little intervention from those who will develop a potentially debilitating headache lasting months to years. The aim of this review is to highlight promising biomarkers for identifying youth who will develop persistent post-traumatic headache.Recent findings\n\nMultiple candidate genetic, protein, imaging, electrophysiological, and digital biomarkers have been identified to help differentiate youth who will develop persistent headache from traumatic brain injury from those who will recover. Promising directions include biomarkers that overlap between traumatic brain injury and migraine. However, no biomarkers are ready for standard use in clinical care. While further work is needed to develop and validate clinically reliable biomarkers of post-traumatic headache in the pediatric population, myriad candidate biomarkers hold promise and warrant further study.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. pattersonc@chop.edu.",
    "Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. pattersonc@chop.edu.",
    "Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Carlyn Patterson Gentile",
      "orcid": "0000-0003-4996-2457"
    },
    {
      "affs": [
        2
      ],
      "name": "Ramon Diaz-Arrastia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/85vxk3xvb50xb.bib",
  "cited_by": 0,
  "doi": "10.1007/s11916-026-01571-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13722807",
  "id": "85vxk3xvb50xb",
  "issns": [
    "1531-3433",
    "1534-3081"
  ],
  "landing_url": "https://europepmc.org/article/MED/42961764",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2713|Traumatic Brain Injury Research"
    ]
  ],
  "openalex": "W7224953315",
  "pdf_url": "https://europepmc.org/articles/PMC13722807?pdf=render",
  "pmcid": "PMC13722807",
  "pmid": "42961764",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/85vxk3xvb50xb.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:21Z",
      "native_id": "MED:42961764",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42961764"
    },
    {
      "first_seen": "2026-11-04T12:21:33Z",
      "native_id": "PMC13722807",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s11916-026-01571-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Traumatic Brain Injury Research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Biomarkers for Post-Traumatic Headache in Youth.",
  "title_text": "Biomarkers for Post-Traumatic Headache in Youth.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:33Z",
  "url": "https://research.draconitic.com/paper/85vxk3xvb50xb",
  "venue": "Current pain and headache reports",
  "versions": []
}