{
  "abstract": "A recent review on Penicillium species highlighted steroids as a taxonomic marker of this genus. In the current study, three steroids (1–3), an acetophenone (4), and thirteen known compounds (5–17) were isolated from the solid culture of Penicillium tanzanicum, isolated from bull dung. The structures of the compounds were established using extensive spectroscopic and spectrometric analyses (NMR, HRMS) and by comparison with published data. The absolute configurations of steroids 1–3 were determined by electronic circular dichroism (ECD) calculations, confirming their identities as trestione (1), formestane (2), and oxandrolone (3). The crude extract exhibited moderate activity against Mycobacterium tuberculosis (MIC = 400 µg mL−1) and significant activity against Enterococcus faecalis and E. faecium (MIC = 50 µg mL−1). Compounds 8, 9, 11, and 13 displayed weak to moderate antibacterial and antimycobacterial activities against M. tuberculosis, Staphylococcus aureus, E. faecalis, and E. faecium, with MIC values ranging from 50 to 100 µg mL−1. Notably, compounds 1 and 2 demonstrated promising antiplasmodial activity against the multi-resistant Plasmodium falciparum (PfDd2) strain, with IC50 values of 26.58 and 15.03 µM, respectively, accompanied by low haemolytic effects. These findings underscore the potential of fungi from underexplored ecological niches as sources of new anti-infective leads warranting further optimisation and preclinical evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Higher Teacher Training College, University of Yaoundé I P.O. Box 47 Yaoundé Cameroon",
    "Department of Organic Chemistry, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaoundé Cameroon",
    "Department of Chemistry, Faculty of Science, University of Buea P.O. Box 63 Buea Cameroon",
    "Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Universitätsstrasse 1 40225 Düsseldorf Germany",
    "Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaounde Cameroon",
    "Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena via A. Moro 2 Siena 53100 Italy",
    "H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi Karachi-75270 Pakistan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Joseph Tchamgoue",
      "orcid": "0000-0002-0506-9678"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Bel Youssouf G. Mountessou",
      "orcid": "0000-0001-7220-3358"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Terence Yocktan D. Yepdjou"
    },
    {
      "affs": [
        3
      ],
      "name": "Aron Trucksess",
      "orcid": "0009-0008-2270-3045"
    },
    {
      "affs": [
        3
      ],
      "name": "Lasse van Geelen",
      "orcid": "0000-0003-3879-4136"
    },
    {
      "affs": [
        4
      ],
      "name": "Kevin Jordan N. Tchoffo"
    },
    {
      "affs": [
        4
      ],
      "name": "Mariscal Brice T. Tali",
      "orcid": "0000-0002-3003-5234"
    },
    {
      "affs": [
        5
      ],
      "name": "Simone Veglianti",
      "orcid": "0009-0005-4688-3165"
    },
    {
      "affs": [
        5
      ],
      "name": "Daniele Padula",
      "orcid": "0000-0002-7171-7928"
    },
    {
      "affs": [
        6
      ],
      "name": "Ayaz Ahmed",
      "orcid": "0000-0001-8792-7850"
    },
    {
      "affs": [
        3
      ],
      "name": "Rainer Kalscheuer",
      "orcid": "0000-0002-3378-2067"
    },
    {
      "affs": [
        0
      ],
      "name": "Simeon F. Kouam",
      "orcid": "0000-0003-0191-0527"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/860010e2rh9wd.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06849a",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656012/?tool=EBI",
  "id": "860010e2rh9wd",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13656012",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2736|Microbial Natural Products and Biosynthesis"
    ]
  ],
  "openalex": "W7221554122",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656012/pdf/?tool=EBI",
  "pmcid": "PMC13656012",
  "pmid": "42866248",
  "published": "2026-10-12",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/860010e2rh9wd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:25Z",
      "native_id": "PMC:PMC13656012",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13656012"
    },
    {
      "first_seen": "2026-11-01T12:23:35Z",
      "native_id": "PMC13656012",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra06849a"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Microbial Natural Products and Biosynthesis",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Sterol-like natural products and other secondary metabolites with antimicrobial and antiplasmodial activities from Penicillium tanzanicum",
  "title_text": "Sterol-like natural products and other secondary metabolites with antimicrobial and antiplasmodial activities from Penicillium tanzanicum",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:49Z",
  "url": "https://research.draconitic.com/paper/860010e2rh9wd",
  "venue": "RSC advances",
  "versions": []
}