{
  "abstract": "Platelet activation is traditionally viewed as a signaling process initiated by receptor engagement. In this issue of The FEBS Journal, Govatati et al. identify an additional regulatory layer linking lipid metabolism to receptor trafficking. The authors show that ALOX15‐derived lipid mediators promote PKCθ‐NMT1‐dependent myristoylation of PAR4, thereby facilitating its membrane localization and platelet activation. These findings position receptor lipidation and trafficking as active regulatory mechanisms in platelet activation and suggest new opportunities for therapeutic modulation of hemostasis.",
  "abstract_shown": true,
  "affiliations": [
    "Cardiovascular Biology Laboratory International Centre for Genetic Engineering and Biotechnology (ICGEB) Trieste Italy",
    "Doctoral Study Programme of Molecular Genetics and Biotechnology, Gradute School University of Nova Gorica Nova Gorica Slovenia",
    "Department of Medicine, Surgery and Health Sciences University of Trieste Trieste Italy"
  ],
  "article_type": "article commentary",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yosef Eshetie Amare"
    },
    {
      "affs": [
        0
      ],
      "name": "Sharad Saxena"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Serena Zacchigna",
      "orcid": "0000-0001-6705-3076"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/868x74f71qh4s.bib",
  "cited_by": 0,
  "doi": "10.1111/febs.70637",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731927/",
  "id": "868x74f71qh4s",
  "issns": [
    "1742-464X",
    "1742-4658"
  ],
  "landing_url": "https://doi.org/10.1111/febs.70637",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Commentary"
    ],
    [
      "openalex",
      "2720|Platelet Disorders and Treatments"
    ]
  ],
  "openalex": "W7166581497",
  "pdf_url": null,
  "pmcid": "PMC13731927",
  "pmid": "42366924",
  "published": "2026-06-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/868x74f71qh4s.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:01Z",
      "native_id": "PMC13731927",
      "source": "pmc",
      "url": "https://doi.org/10.1111/febs.70637"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Protein Structure and Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "ALOX15 links lipid metabolism to receptor trafficking in platelet activation",
  "title_text": "ALOX15 links lipid metabolism to receptor trafficking in platelet activation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:01Z",
  "url": "https://research.draconitic.com/paper/868x74f71qh4s",
  "venue": "The Febs Journal",
  "versions": []
}