{
  "abstract": "Background/Objectives: Perforated peptic ulcer (PPU) is a serious clinical condition requiring emergency surgery and continues to carry a significant risk of mortality. This study evaluated factors associated with in-hospital mortality and the discriminatory performance of admission parameters. Methods: We retrospectively studied 385 adults who underwent emergency surgery for PPU between January 1999 and December 2025. Survivors and non-survivors were compared using nonparametric tests for continuous variables. A multivariable logistic regression model included 265 complete cases (40 deaths), and selected admission variables were evaluated using receiver operating characteristic (ROC) analysis. Results: In-hospital mortality occurred in 49 patients (12.7%). Non-survivors were older (median 76.50 vs. 55.00 years; p < 0.001) and had lower hemoglobin (12.30 vs. 14.90; p < 0.001) and higher BUN levels (36.00 vs. 21.00; p < 0.001). Time from symptom onset to admission did not differ significantly between groups (median 24 vs. 16 h; p = 0.471). After adjustment, ASA class remained associated with mortality (adjusted OR 5.404; 95% CI 2.640–11.064; p < 0.001), whereas BUN did not (adjusted OR 1.010; 95% CI 0.988–1.032; p = 0.378). ROC AUC values were 0.801 for ASA, 0.788 for age, and 0.749 for BUN. Conclusions: ASA class was independently associated with in-hospital mortality in this cohort. Although BUN showed discrimination in ROC analysis, its adjusted association was not statistically significant. Findings and exploratory cut-offs require external validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, Division of Gastroenterological Surgery, Faculty of Medicine, İnönü University, 44280 Malatya, Türkiye",
    "Department of General Surgery, Faculty of Medicine, İnönü University, 44280 Malatya, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Egemen Cicek",
      "orcid": "0000-0003-2691-7418"
    },
    {
      "affs": [
        1
      ],
      "name": "Cem Deniz Ayıkol",
      "orcid": "0009-0000-7309-1626"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/86a5y98kta92n.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218553",
  "fulltext_url": null,
  "id": "86a5y98kta92n",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8553",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/86a5y98kta92n.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:42Z",
      "native_id": "10.3390/jcm15218553",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8553"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Early Risk Stratification for In-Hospital Mortality in Patients Undergoing Emergency Surgery for Perforated Peptic Ulcer: A 27-Year Retrospective Cohort Study",
  "title_text": "Early Risk Stratification for In-Hospital Mortality in Patients Undergoing Emergency Surgery for Perforated Peptic Ulcer: A 27-Year Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/86a5y98kta92n",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}