{
  "abstract": "With advances in molecular profiling and targeted therapies for non-small cell lung cancer(NSCLC),central nervous system(CNS)involvement and its management in patients with rare driver-gene alterations have received increasing attention. The development of next-generation small-molecule inhibitors and antibody-drug conjugates(ADCs)has improved intracranial disease control in some patients; however,the level of evidence for intracranial treatment varies substantially across different driver alterations,and data on CNS-specific endpoints remain limited. The rational integration of targeted therapies with local treatments,such as stereotactic radiosurgery(SRS),together with multidisciplinary team(MDT)integrated management,has become an important therapeutic strategy. This review summarizes the clinical and molecular characteristics of brain metastases in NSCLC harboring rare driver-gene alterations,with a focus on advances in systemic therapies and multidisciplinary treatment strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Oncology,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,The Affiliated CancerHospital of Nanjing Medical University,Nanjing,Jiangsu 210009,China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "CHEN Xi"
    },
    {
      "name": "LIU Ying"
    },
    {
      "name": "LI Feiyang"
    },
    {
      "name": "HU Shuyi"
    },
    {
      "name": "WU Sirui"
    },
    {
      "name": "FANG Ying"
    },
    {
      "name": "SHA Huanhuan"
    },
    {
      "name": "ZHOU Guoren"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/86hq5nwyp8arf.bib",
  "cited_by": 0,
  "doi": "10.13429/j.cnki.cjcr.2026.10.002",
  "fulltext_url": "http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20261002",
  "id": "86hq5nwyp8arf",
  "issns": [
    "1674-8182"
  ],
  "landing_url": "https://doi.org/10.13429/j.cnki.cjcr.2026.10.002",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2740|Brain Metastases and Treatment"
    ]
  ],
  "openalex": "W7224086960",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "The Editorial Department of Chinese Journal of Clinical Research",
  "ris": "https://research.draconitic.com/paper/86hq5nwyp8arf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:07Z",
      "native_id": "f101e345ae4c483f93091e27b6c182d7",
      "source": "doaj",
      "url": "https://doi.org/10.13429/j.cnki.cjcr.2026.10.002"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Brain Metastases and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Advances in the treatment of brain metastases in non-small cell lung cancer with rare driver-gene alterations",
  "title_text": "Advances in the treatment of brain metastases in non-small cell lung cancer with rare driver-gene alterations",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:07Z",
  "url": "https://research.draconitic.com/paper/86hq5nwyp8arf",
  "venue": "Zhongguo linchuang yanjiu",
  "versions": []
}