{
  "abstract": "Coronary artery disease (CAD) is a leading cause of death worldwide and is associated with standard modifiable cardiovascular risk factors (SMuRFs); however, additional factors may contribute to its development. Bisphenol A (BPA), an endocrine-disrupting chemical has been associated with cardiovascular alterations. We investigated BPA’s possible association with classic risk factors and vascular injury biomarkers in Mexican patients with CAD. Adult patients underwent quantitative coronary angiography and SYNTAX score assessment and were classified as having obstructive (OD) or non-obstructive (NOD) disease. SMuRFs, lipid profile, VCAM-1, MMP-2, MMP-9, and uBPA were determined. Data were analyzed using correlation analysis, Welch’s t-test, ANOVA, and adjusted multiple linear regression. Eighty-nine patients aged 30–85 years were evaluated. OD patients had higher uBPA levels (3.46 ± 2.04 ng/mL) than NOD patients (1.25 ± 1.08 ng/mL), and uBPA levels differed according to the number of diseased arteries and diseased artery segments. uBPA was positively associated with MMP-2, MMP-9, SYNTAX score, percentage of stenosis, number of diseased arteries, diseased artery segments, and SMuRFs, and negatively associated with HDLc. SYNTAX score was associated with MMP-2, MMP-9, VCAM-1 and low HDLc levels. Our findings support uBPA levels are associated with vascular injury in Mexican patients with coronary artery disease.",
  "abstract_shown": true,
  "affiliations": [
    "Centro de Investigación Biomédica Avanzada, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Querétaro 76140, Mexico",
    "Centro de Estudios Clínicos de Querétaro, Santiago de Querétaro 76000, Mexico",
    "Instituto de Corazón de Querétaro, Santiago de Querétaro 76000, Mexico",
    "Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Santiago de Querétaro 76230, Mexico"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Fernando Manuel Guerrero-Meza",
      "orcid": "0000-0003-2925-4867"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Marco Antonio Alcocer-Gamba",
      "orcid": "0000-0003-2033-2494"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Juan Pablo Núñez-Urquiza"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Rafael Vera-Urquiza"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Aquiles Montalvo-Ramos"
    },
    {
      "affs": [
        3
      ],
      "name": "Santiaga Marisela Ahumada-Solórzano",
      "orcid": "0000-0002-6779-4859"
    },
    {
      "affs": [
        0
      ],
      "name": "Haydé Azeneth Vergara-Castañeda",
      "orcid": "0000-0001-8926-2223"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Juan Carlos Solís-Sáinz"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ana Gabriela Hernández-Puga",
      "orcid": "0000-0001-9040-3521"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/86n2jndec3xp0.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27209295",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705455/?tool=EBI",
  "id": "86n2jndec3xp0",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/20/9295",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2307|Effects and risks of endocrine disrupting chemicals"
    ]
  ],
  "openalex": "W7223048668",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705455/pdf/?tool=EBI",
  "pmcid": "PMC13705455",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/86n2jndec3xp0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27209295",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/20/9295"
    },
    {
      "first_seen": "2026-10-30T12:21:47Z",
      "native_id": "PMC:PMC13705455",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705455"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Effects and risks of endocrine disrupting chemicals",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Urinary Bisphenol A Levels Are Associated with Vascular Injury in Mexican Patients with Coronary Artery Disease",
  "title_text": "Urinary Bisphenol A Levels Are Associated with Vascular Injury in Mexican Patients with Coronary Artery Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:47Z",
  "url": "https://research.draconitic.com/paper/86n2jndec3xp0",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}