{
  "abstract": "This case series examines the clinical and radiographic outcomes of central giant cell granulomas (CGCG) of the mandible treated with enucleation, liquid nitrogen cryotherapy, and recombinant human bone morphogenetic protein-2 (rhBMP-2) augmented bone grafting. Five patients were treated with this surgical technique. All patients demonstrated complete radiographic ossification within 6–12 months, without recurrence or major complication. In all patients whose dentition was resected with the pathologic bone (2 of 5), complete dental rehabilitation was achieved, demonstrating functional bone regeneration. This series represents a reliable middle ground between curettage and segmental resection.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oral and Maxillofacial Surgery, Highland Hospital, Alameda Health System, Oakland, CA, USA",
    "Department of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA; Corresponding author. 3600 Broadway St., 4th Floor Suite 41, Oakland, CA 94611, USA.",
    "Department of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Richard Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jason Middleton"
    },
    {
      "affs": [
        2
      ],
      "name": "Heshaam Fallah"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/86z8ypbbaggzq.bib",
  "cited_by": 0,
  "doi": "10.1016/j.adoms.2026.100738",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2667147626001202",
  "id": "86z8ypbbaggzq",
  "issns": [
    "2667-1476"
  ],
  "landing_url": "https://doi.org/10.1016/j.adoms.2026.100738",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC31-1245"
    ],
    [
      "lcc",
      "RD1-811"
    ],
    [
      "openalex",
      "3504|Oral and Maxillofacial Pathology"
    ]
  ],
  "openalex": "W7215091244",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2667147626001202/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/86z8ypbbaggzq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:42Z",
      "native_id": "6f44d6ae3ef6476db519b594b9c93e65",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.adoms.2026.100738"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RD1-811",
      "subfield": "surgery"
    }
  ],
  "title": "Efficacy of cryotherapy as an adjunctive treatment for mandibular central giant cell granuloma: A case series",
  "title_text": "Efficacy of cryotherapy as an adjunctive treatment for mandibular central giant cell granuloma: A case series",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:42Z",
  "url": "https://research.draconitic.com/paper/86z8ypbbaggzq",
  "venue": "Advances in Oral and Maxillofacial Surgery",
  "versions": []
}