{
  "abstract": "PurposeThis study aims to compare the effects of a multimodal analgesia regimen including sufentanil, esketamine, and dexmedetomidine with the traditional morphine-only analgesia approach on postoperative bowel recovery in pediatric liver transplant patients.MethodsThis is a single-center retrospective cohort study. The medical records of a total of 82 infants who underwent liver transplantation at Renji Hospital, from September 2022 to March 2023 were included. Patients were divided into two groups based on the postoperative analgesia regimen: the morphine group (M group), which used morphine only, and the multimodal analgesia group (MMA group), which used sufentanil in combination with esketamine and dexmedetomidine.ResultsThe patients’ ages ranged from 4 to 12 months, and the mean preoperative pediatric end-stage liver disease (PELD) scores were 18.7 and 21.9. General linear model analysis revealed that the MMA group had a significantly shorter time to first bowel movement and shorter mechanical ventilation duration. Multivariate analysis further indicated that the use of multimodal analgesia significantly accelerated time to first defecation by approximately 20.6 h.ConclusionCompared to using morphine alone for postoperative analgesia, the combination of sufentanil, esketamine, and dexmedetomidine for postoperative analgesia in liver transplant infants is more beneficial for brecovery and facilitates early postoperative extubation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China",
    "Key Laboratory of Anesthesiology, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China",
    "Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China",
    "Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ling Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Ling Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiabei He"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiabei He"
    },
    {
      "affs": [
        2
      ],
      "name": "Leiqing Gao"
    },
    {
      "affs": [
        3
      ],
      "name": "Yuxiao Deng"
    },
    {
      "affs": [
        0
      ],
      "name": "Bo Qi"
    },
    {
      "affs": [
        1
      ],
      "name": "Bo Qi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/86zennv3tkyka.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1962570",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fmed.2026.1962570/full",
  "id": "86zennv3tkyka",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://doi.org/10.3389/fmed.2026.1962570",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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  "pdf_url": "https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1962570/pdf",
  "pmcid": "PMC13739776",
  "pmid": "42996352",
  "published": "2026-10-23",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/86zennv3tkyka.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:47Z",
      "native_id": "4b6d88b787f347d895d36dfd9e1f7156",
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      "url": "https://doi.org/10.3389/fmed.2026.1962570"
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  "subjects": [
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      "origin": "openalex:2746|Anesthesia and Pain Management",
      "subfield": "surgery"
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  "title": "Multimodal analgesic regimen is associated with earlier bowel recovery in infants undergoing liver transplantation: a cohort study",
  "title_text": "Multimodal analgesic regimen is associated with earlier bowel recovery in infants undergoing liver transplantation: a cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/86zennv3tkyka",
  "venue": "Frontiers in Medicine",
  "versions": []
}