{
  "abstract": "Recent advances in chromoselective photoredox catalysis have demonstrated that light wavelength can serve as a powerful and orthogonal reaction parameter, enabling divergent reactivity from a single catalytic system. Building on recent advances in the sequential decarboxylative/defluorinative aminoalkylation of trifluoromethyl-substituted alkenes, we report a divergent, wavelength-dependent strategy for the site-selective functionalization of N-arylglycines. High-throughput experimentation (HTE) was used to systematically screen photocatalysts and irradiation wavelengths to identify the most suitable divergent conditions. Interestingly, using [Ru(bpy)3]2+ as photocatalyst, irradiation with blue light promotes efficient difunctionalization of CF3-alkenes with N-arylglycines, affording monofluoroalkenyl-1,5-diamines, while switching the irradiation to red light enables selective monofunctionalization, delivering the corresponding gem-difluoroalkenyl amine intermediates exclusively under otherwise identical conditions, via a spin-forbidden transition pathway. This wavelength-governed switchable reactivity provides a powerful and tunable platform for the controlled radical modification of amino acids, expanding the synthetic utility of visible-light photoredox catalysis in divergent amine synthesis. Mechanistic investigations using photoelectrochemistry and TD-DFT have revealed notably a photo-excitation of intermediates, allowing for the second functionalization to whether happens or not, based on the irradiation wavelength used.",
  "abstract_shown": true,
  "affiliations": [
    "SCBM",
    "Université Paris-Saclay",
    "CEA, CNRS, NIMBE, Université Paris-Saclay",
    "Département de Chimie",
    "École Normale Supérieure, PSL University, Sorbonne Université, CNRS"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Marine Le Stum"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maria Eduarda Candido Thedy"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Taline Kerackian"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jean-Christophe Cintrat"
    },
    {
      "affs": [
        2
      ],
      "name": "Emmanuel Nicolas"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Laurence Grimaud"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Eugénie Romero",
      "orcid": "0000-0003-0484-1221"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/87665tjgh77fz.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15010275/v1",
  "fulltext_url": null,
  "id": "87665tjgh77fz",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010275/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Radical Photochemical Reactions"
    ]
  ],
  "openalex": "W7221532684",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15010275/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/87665tjgh77fz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15010275",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010275/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Radical Photochemical Reactions",
      "subfield": "organic"
    }
  ],
  "title": "Chromoselective Control for Aminoalkylation of CF3‑Alkenes through Low-Energy Photoredox Catalysis",
  "title_text": "Chromoselective Control for Aminoalkylation of CF3‑Alkenes through Low-Energy Photoredox Catalysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/87665tjgh77fz",
  "venue": "ChemRxiv",
  "versions": []
}