{
  "abstract": "Introduction: Alport syndrome is a rare hereditary disorder caused by type IV collagen abnormalities and characterized by progressive kidney disease with variable extrarenal manifestations. Evidence guiding anesthetic management, particularly in pediatric patients, remains limited.\n\nCase presentation: We report the anesthetic management of a 12-year-old girl with a clinical diagnosis of X-linked Alport syndrome based on microscopic hematuria and obligate heterozygosity for a familial pathogenic COL4A5 variant undergoing elective lower-leg surgery in the prone position. Despite preserved renal function, perioperative management included careful drug selection and a propofol-based total intravenous anesthesia using a second-generation laryngeal mask airway without neuromuscular blockade. Stable ventilation was maintained throughout prone surgery, and recovery was uncomplicated with effective postoperative pain control.\n\nConclusions: This case contributes to the limited literature on anesthetic management in pediatric Alport syndrome and highlights practical perioperative considerations regarding airway management, anesthetic technique, and renal-protective care.",
  "abstract_shown": true,
  "affiliations": [
    "Philipps-Universität Marburg, Marburg, Germany",
    "Department of Anesthesiology and Operative Intensive Care Medicine, University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany",
    "Department of Pediatric Anesthesia and Intensive Care Medicine, Klinikum Kassel, Kassel, Germany"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Christine Gaik"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Selena Knoth"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Felix Schmitt"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ingelore Holzinger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/876e4tqd9w53h.bib",
  "cited_by": 0,
  "doi": "10.3389/fped.2026.1950654",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731332/",
  "id": "876e4tqd9w53h",
  "issns": [
    "2296-2360"
  ],
  "landing_url": "https://doi.org/10.3389/fped.2026.1950654",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2703|Anesthesia and Sedative Agents"
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  "openalex": "W7223147979",
  "pdf_url": "https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1950654/pdf",
  "pmcid": "PMC13731332",
  "pmid": "42984855",
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/876e4tqd9w53h.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:33Z",
      "native_id": "PMC13731332",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fped.2026.1950654"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2703|Anesthesia and Sedative Agents",
      "subfield": "surgery"
    }
  ],
  "title": "Anesthetic challenges in a child with Alport syndrome undergoing prone surgery with a laryngeal mask airway: a case report",
  "title_text": "Anesthetic challenges in a child with Alport syndrome undergoing prone surgery with a laryngeal mask airway: a case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:33Z",
  "url": "https://research.draconitic.com/paper/876e4tqd9w53h",
  "venue": "Frontiers in Pediatrics",
  "versions": []
}