{
  "abstract": "Post-COVID-19 condition can include persistent cognitive symptoms, commonly described as impaired attention, memory difficulties, slowed processing, and “brain fog.” Clinical and translational evidence implicates systemic inflammation, neurovascular dysfunction, blood–brain barrier disruption, glial inflammatory responses, oxidative stress, and altered synaptic or network function; their relative contributions remain uncertain and may differ across patient subgroups. Resveratrol is a polyphenolic compound that modifies inflammatory, redox, metabolic, endothelial, and antiviral pathways in experimental systems. This focused narrative review examines whether those actions provide a mechanistic basis for the use of resveratrol in post-COVID-19 cognitive dysfunction. Evidence was considered according to biological proximity to the intended indication, distinguishing human post-acute sequelae of SARS-CoV-2 infection (PASC) studies from acute-COVID-19, non-COVID-19 clinical, animal, organoid, and cell-based evidence. The review identifies candidate neurovascular, immune, and metabolic processes, evaluates where resveratrol evidence intersects with those processes, and distinguishes molecular observations from clinical questions that remain to be tested for to define the therapeutic potential of using resveratrol to treat post-COVID-19 cognitive impairment.",
  "abstract_shown": true,
  "affiliations": [
    "Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autónoma de Zacatecas, Zacatecas-Guadalajara km. 6, Ejido La Escondida, Zacatecas 98160, Mexico",
    "Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501, Monterrey 64849, Mexico"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Margarita L. Martinez-Fierro",
      "orcid": "0000-0003-1478-9068"
    },
    {
      "affs": [
        0
      ],
      "name": "Samantha Gonzalez-Delgado",
      "orcid": "0009-0006-0415-5730"
    },
    {
      "affs": [
        0
      ],
      "name": "Israel A. Solis-Hernandez",
      "orcid": "0009-0001-1837-409X"
    },
    {
      "affs": [
        1
      ],
      "name": "Maria del R. Rocha-Pizaña",
      "orcid": "0000-0003-1575-940X"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana J. Mendez-Gonzalez",
      "orcid": "0009-0002-9807-8262"
    },
    {
      "affs": [
        0
      ],
      "name": "Idalia Garza-Veloz",
      "orcid": "0000-0002-6307-1696"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/878m8ejkg030h.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31203747",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707633/?tool=EBI",
  "id": "878m8ejkg030h",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/20/3747",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Long-Term Effects of COVID-19"
    ]
  ],
  "openalex": "W7222937925",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707633/pdf/?tool=EBI",
  "pmcid": "PMC13707633",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/878m8ejkg030h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31203747",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/20/3747"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13707633",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13707633"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Long-Term Effects of COVID-19",
      "subfield": "neurology"
    }
  ],
  "title": "Resveratrol for Post-COVID-19 Cognitive Dysfunction: From Molecular Basis to Clinical Translation",
  "title_text": "Resveratrol for Post-COVID-19 Cognitive Dysfunction: From Molecular Basis to Clinical Translation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/878m8ejkg030h",
  "venue": "Molecules",
  "versions": []
}