{
  "abstract": "Oxylipin research has undergone a profound transformation since the first discovery of an oxygenated metabolite of fatty acid, evolving from the identification of enzymatically produced lipid mediators to the study of complex bioactive lipid networks. The discovery of numerous non-enzymatic oxidation products has considerably expanded the oxylipin landscape, while advances in organic synthesis have enabled their syntheses as well as their structural characterization, stereochemical assignment, and biological investigations. Concurrently, developments in mass spectrometry and lipidomics have revolutionized oxylipin analysis, allowing the comprehensive profiling of hundreds of metabolites in a single injection setting. More recently, molecular networking has shifted the focus from individual compounds to interconnected lipid networks. This review highlights the major milestones that have shaped the field and discusses emerging strategies integrating chemistry, biology, analytical science, and computational approaches to accelerate the discovery of new bioactive oxylipins. The convergence of these disciplines is expected to drive predictive lipidomics, network-guided discovery and synthesis, and the development of more sustainable synthetic strategies for identifying and engineering the next generation of bioactive lipid mediators.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Camille Oger"
    },
    {
      "name": "Jean-Marie Galano"
    },
    {
      "name": "Thierry Durand"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/878zqq6hay6bx.bib",
  "cited_by": 0,
  "doi": "10.5802/crchim.485",
  "fulltext_url": null,
  "id": "878zqq6hay6bx",
  "issns": [
    "1631-0748",
    "1878-1543"
  ],
  "landing_url": "https://hal.science/hal-05855627v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1312|Metabolomics and Mass Spectrometry Studies"
    ]
  ],
  "openalex": "W7225226366",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-04",
  "publisher": "Académie des sciences (Paris)",
  "ris": "https://research.draconitic.com/paper/878zqq6hay6bx.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:26Z",
      "native_id": "hal-05855627",
      "source": "hal",
      "url": "https://hal.science/hal-05855627v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Metabolomics and Mass Spectrometry Studies",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Nearly a century exploring oxylipins",
  "title_text": "Nearly a century exploring oxylipins",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:49Z",
  "url": "https://research.draconitic.com/paper/878zqq6hay6bx",
  "venue": "Comptes Rendus. Chimie",
  "versions": []
}