{
  "abstract": "BackgroundCoronary microvascular dysfunction (CMD or CMVD), a major subtype of angina with non-obstructive coronary arteries, affects a substantial proportion of patients and represents an important unmet clinical need, particularly in China. Studies evaluating comparative treatment efficacy in angina populations, especially across CMVD and non-CMVD, remain limited.ObjectiveTo assess the efficacy of different therapeutic regimens (nicorandil vs. non-nicorandil treatment) among angina pectoris patients with CMVD.MethodsWe conducted a retrospective analysis of baseline and follow-up data from nine centres of the GREAT study, including patients with angina from nine hospitals in China treated with nicorandil or non-nicorandil regimens. Patients with and without CMVD (coronary angiography-derived index of microvascular resistance [caIMR], ≥25 vs. < 25) were included, and post-treatment differences in Seattle Angina Questionnaire (SAQ) scores were compared between groups.ResultsA total of 1,259 patients with angina were included in this study. Among them, 429 patients had CMVD (caIMR ≥25), comprising 170 in the nicorandil group and 259 in the non-nicorandil group, while 830 patients did not have CMVD (nicorandil group, 319; non-nicorandil group, 511). After propensity score matching, the mean SAQ summary score (SAQ-SS) improvement in patients with CMVD, was greater in the nicorandil group than in the non-nicorandil group (mean change: 16.80 vs. 12.60, P = 0.044). Among patients without CMVD, nicorandil therapy resulted in significantly greater SAQ-SS improvement at respective timepoints (3 months: 15.68 vs. 12.15, P = 0.005; 6 months: 18.70 vs. 14.44, P < 0.001; 9 months: 18.11 vs. 15.07, P = 0.008).ConclusionNicorandil-based regimens may be associated with greater improvement in health status among angina patients with CMVD compared with non-nicorandil treatments.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Original Research",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Yang Zhang"
    },
    {
      "name": "Su’e Xu"
    },
    {
      "name": "Litao Wu"
    },
    {
      "name": "Yajuan Liu"
    },
    {
      "name": "Xin Du"
    },
    {
      "name": "Guojie Cheng"
    },
    {
      "name": "Liling Sun"
    },
    {
      "name": "Ying Wei"
    },
    {
      "name": "Wei Liu"
    },
    {
      "name": "Lifu Miao"
    },
    {
      "name": "Qihua Zhang"
    },
    {
      "name": "Changsheng Ma"
    },
    {
      "name": "Yong Zeng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/87gmpgk32dh0x.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1938738",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1938738/full",
  "id": "87gmpgk32dh0x",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1938738",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/pharmacology-toxicology"
    ],
    [
      "lcc",
      "RM1-950"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/87gmpgk32dh0x.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T06:20:23Z",
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      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1938738"
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      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1938738/full"
    },
    {
      "first_seen": "2026-11-02T14:21:12Z",
      "native_id": "06a1e3e1b6704d1d8b8c252877dcdf82",
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      "url": "https://doi.org/10.3389/fphar.2026.1938738"
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  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/pharmacology-toxicology",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Clinical outcomes of angina treatment in coronary microvascular dysfunction: results of a multicenter observational study",
  "title_text": "Clinical outcomes of angina treatment in coronary microvascular dysfunction: results of a multicenter observational study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T14:20:14Z",
  "url": "https://research.draconitic.com/paper/87gmpgk32dh0x",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}