{
  "abstract": "Early cognitive response after repetitive transcranial magnetic stimulation (rTMS) may predict later cognitive change in Alzheimer disease, but the incremental value of domain-specific response is unclear. We analyzed data from 112 randomized participants; 101 entered a Week-5 landmark cohort and 91 had complete predictors and outcomes at 8, 16, and 24 weeks post-treatment. Nested predictor-set comparisons used ridge regression to evaluate baseline information, trial variables, early total-score response, and domain-specific response. Model-class comparisons included ridge, multi-task elastic net, restricted random forest, and longitudinal mixed effects. Validation used repeated treatment-site-stratified 5-fold cross-validation with five repetitions, nested hyperparameter tuning, and paired participant-level bootstrap comparisons with 10,000 resamples. Adding Week-3 and Week-5 ADAS-Cog total-score response improved prediction. The early total-response ridge achieved overall MAE 3.067, RMSE 3.885, and $R^2=0.384$. Replacing two total-response variables with 22 component-level changes worsened performance (MAE 3.363, RMSE 4.269, $R^2=0.257$). The paired MAE difference was -0.297 points (95% CI -0.485 to -0.115). Mixed effects was competitive (MAE 3.162), with an uncertain overall difference from total-response ridge. Sensitivity analyses using absolute future scores and excluding Week-3 response supported the main findings. In this sample, early aggregate ADAS-Cog response was more informative than a higher-dimensional domain-specific representation. The model is an internally validated early-response updating tool, not a pretreatment selection model or evidence of causal rTMS efficacy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2610.09629",
  "author_total": 2,
  "authors": [
    {
      "name": "Mohammad Alamgir Chowdhury"
    },
    {
      "name": "Hina Shaheen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/87gsnf303fetr.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2610.09629",
  "fulltext_url": null,
  "id": "87gsnf303fetr",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2610.09629",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "q-bio.NC"
    ],
    [
      "arxiv",
      "stat.AP"
    ],
    [
      "openalex",
      "2808|Transcranial Magnetic Stimulation Studies"
    ]
  ],
  "openalex": "W7221056992",
  "pdf_url": "https://arxiv.org/pdf/2610.09629",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/87gsnf303fetr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:43Z",
      "native_id": "2610.09629",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2610.09629"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "arxiv:q-bio.NC",
      "subfield": "neuroscience"
    },
    {
      "field": "mathematics",
      "origin": "arxiv:stat.AP",
      "subfield": "statistics"
    }
  ],
  "title": "Predicting Long-Term ADAS-Cog Change From Early Response After Repetitive Transcranial Magnetic Stimulation in Alzheimer Disease",
  "title_text": "Predicting Long-Term ADAS-Cog Change From Early Response After Repetitive Transcranial Magnetic Stimulation in Alzheimer Disease",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:48Z",
  "url": "https://research.draconitic.com/paper/87gsnf303fetr",
  "venue": "arXiv",
  "versions": []
}