{
  "abstract": "Self-derived double-stranded RNAs (self-dsRNAs) can drive autoinflammation, but how structurally constrained self-dsRNAs become immunostimulatory remains unclear. We identify a noncanonical role for Dicer and a broad requirement for LGP2 in this process. Dicer is required for responses to self-dsRNAs, but not exogenous dsRNAs, that arise from defects in RNA editing, splicing, epigenetic silencing, or mitochondrial RNA degradation in multiple cell types, including a human stem cell-derived model of neuroinflammation. Independently of microRNA biogenesis, Dicer promotes activation of MDA5, PKR, and OAS-RNase L. Dicer binds immunostimulatory dsRNAs and uses its catalytic activity to generate shorter duplexes with accessible ends that are available for LGP2 end-binding, enabling MDA5 filament assembly. Thus, Dicer converts short, structurally constrained self-dsRNAs into inflammatory ligands, thereby facilitating their recognition as danger-associated signals.",
  "abstract_shown": true,
  "affiliations": [
    "Leiden University Medical Center"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "L. R. ter Haar"
    },
    {
      "name": "S. de Lange"
    },
    {
      "name": "D. Gravekamp"
    },
    {
      "name": "A. R. Kooij"
    },
    {
      "name": "J. W. de Wolf"
    },
    {
      "name": "Y. Asschert"
    },
    {
      "name": "T. Oosenbrug"
    },
    {
      "name": "M. W. Paul"
    },
    {
      "name": "P. A. van Veelen"
    },
    {
      "name": "W. M. C. van Roon-Mom"
    },
    {
      "name": "H. Mei"
    },
    {
      "affs": [
        0
      ],
      "name": "A. G. Van der Veen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/87n7trq93wx9a.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.29.761885",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.761885v1.full",
  "id": "87n7trq93wx9a",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.761885v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.29.761885v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/87n7trq93wx9a.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:04Z",
      "native_id": "10.64898/2026.10.29.761885",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.29.761885v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "A noncanonical function of Dicer fuels self-dsRNA-driven inflammation",
  "title_text": "A noncanonical function of Dicer fuels self-dsRNA-driven inflammation",
  "type": "preprint",
  "updated_at": "2026-11-08T00:20:56Z",
  "url": "https://research.draconitic.com/paper/87n7trq93wx9a",
  "venue": "bioRxiv",
  "versions": []
}